- Stock: In Stock
- Brand: Square Pharmaceuticals
- Product ID: Aceclofenac
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| Generic Name | Aceclofenac |
|---|---|
| Strength | 200 mg |
| Dosage Form | Sustained-Release (SR) Tablet |
| Manufacturer | Square Pharmaceuticals PLC |
| Therapeutic Class | Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, NSAIDs |
| Pack Size | 3 × 10 tablets |
Overview
Flexi SR 200mg Tablet contains Aceclofenac in a sustained-release formulation, providing extended pain and inflammation relief throughout the day. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes and reduces prostaglandin synthesis, the primary mediators of pain and inflammation. The SR formulation allows once-daily dosing, improving patient convenience and compliance. It is indicated for the symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, dental pain, post-traumatic pain, and lumbago.
Dosage and Administration
Adults: One 200 mg SR tablet once daily, preferably with or after food. The sustained-release tablet must be swallowed whole and should not be crushed, chewed, or broken. The lowest effective dose should be used for the shortest duration necessary.
Interaction
Aceclofenac may interact with: Lithium and Digoxin (plasma levels may increase); Diuretics (reduced diuretic efficacy; increased risk of nephrotoxicity); Anticoagulants (enhanced anticoagulant effect; monitor closely); Methotrexate (plasma levels may increase; monitor for toxicity); other NSAIDs and corticosteroids (increased risk of gastrointestinal adverse effects).
Contraindications
Flexi SR 200mg is contraindicated in patients with known hypersensitivity to Aceclofenac, Aspirin, or other NSAIDs, in those with active or history of peptic ulcer disease, NSAID-induced or aspirin-sensitive asthma, urticaria, or rhinitis, and in patients with severe renal, hepatic, or cardiac failure.
Side Effects
Common: dyspepsia, nausea, abdominal pain, diarrhoea, constipation, flatulence. Less common: dizziness, headache, skin rash, pruritus, peripheral oedema. Rare: peptic ulcer, gastrointestinal bleeding, elevated liver enzymes, and renal impairment with prolonged use. Serious GI events may occur, particularly in elderly patients or those on high doses.
Pregnancy and Lactation
Flexi SR 200mg is not recommended during pregnancy, especially in the third trimester, as NSAIDs may cause premature closure of the ductus arteriosus. Use during breastfeeding should be avoided. Consult a physician before use in women of childbearing age.
Precautions and Warnings
Use with caution in patients with a history of peptic ulcer disease, renal or hepatic impairment, cardiovascular disease, or coagulation disorders. The SR tablet must not be crushed or chewed. Avoid concurrent use with other NSAIDs. Long-term use should be periodically reviewed by a physician.
Storage Conditions
Store in a dry place, away from light and heat. Keep out of reach of children.
Frequently Asked Questions
Q: How is Flexi SR 200mg different from Flexi 100mg?
A: Flexi SR 200mg is a sustained-release formulation allowing once-daily dosing. Flexi 100mg requires twice-daily dosing. Both contain Aceclofenac and share the same therapeutic indications.
Q: Can the Flexi SR 200mg tablet be broken or crushed?
A: No. The SR tablet must be swallowed whole. Crushing or breaking it disrupts the controlled-release mechanism and may cause an unintended rapid release of the active ingredient.
