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Meroxin 500 mg IV Injection or Infusion

Meroxin 500 mg IV Injection or Infusion in Bangladesh,Meroxin 500 mg IV Injection or Infusion price,usage of Meroxin 500 mg IV Injection or Infusion
Meroxin 500 mg IV Injection or Infusion
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Meroxin 500 mg IV Injection or Infusion


Description:

Meropenem is a carbapenem antibiotic for parenteral use . It exerts its bactericidal action by interfering with bacterial cell wall synthesis. It penetrates bacterial cell walls, its high level of stability to all serine beta-lactamases and its marked affinity for the Penicillin Binding Proteins (PBPs.). It shows potent bactericidal activity against a broad spectrum of Gram-positive and Gram-negative, aerobic and anaerobic bacteria.


Indication

INDICATION Meropenem IV is indicated for treatment in adults and children for the following infections caused by single or multiple bacteria sensitive to Meropenem.

* Pneumonia and Nosocomial Pneumonia
* Urinary Tract Infections
* Intra-abdominal Infections
* Gynaecological Infections, such as endometritis and pelvic inflammatory disease
* Skin and Skin Structure Infections
* Meningitis
* Septicaemia
* Pulmonary infections in cystic fibrosis
* Empiric treatment for presumed infections in patients with febrile neutropenia

Dosage & Administration

The dosage and duration of therapy shall be established depending on type, severity of infection and the condition of the patient. The recommended daily dosage is as follows:-
Adults: The usual dose is 500 mg to 1 gm by intravenous administration every 8 hours. Pneumonia, urinary tract infections, gynaecological infections such as endometritis, pelvic inflammatory disease, skin and skin structure infections: 500 mg IV every 8 hours. Nosocomial pneumonias, peritonitis, presumed infections in neutropenic patients and septicaemia: 1g IV every 8 hours. Intra-abdominal infections: 500 mg to 1 gm every 8 hours. Cystic fibrosis: Upto 2 gm every 8 hours. Meningitis: 2 gm IV every 8 hours.

Contraindication

Meropenem is contraindicated in patients who have demonstrated hypersensitivity to this product.

Side Effects

Meropenem is generally well tolerated. Side effects like inflammation, thrombophlebitis, pain at the site of injection, skin reactions like rash, pruritus, urticaria, abdominal pain, nausea, vomiting, diarrhea, headache may occur.

Drug Interaction

Probenecid competes with Meropenem for active tubular secretion and thus inhibits the renal excretion, with the effect of increasing the elimination half-life and plasma concentration of meropenem. Meropenem may reduce serum valproic acid levels. Sub therapeutic levels may be reached in some patients.

Overdose

Accidental overdose could occur during therapy, particularly in patients with renal impairment. Treatment of overdose should be symptomatic. In normal individuals, rapid renal elimination will occur; in subjects with renal impairment, haemodialysis will remove Meropenem and its metabolite.

Pregnancy & Lactation

Use in Pregnancy: Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. So this drug should be used during pregnancy only if clearly needed.
Use in Lactation: Because many drugs are excreted in human milk, caution should be exercised when Meropenem is administered to a nursing woman.
Use in Children: Efficacy and tolerability in infants under 3 months have not been established.

Storage Condition

Vial store in a cool, dry place (below 30o C), away from light & moisture. Keep out of the reach of children.

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