Metfo 850 tab

Metfo 850 Tablet — Metformin Hydrochloride

Overview

Metfo 850 is a higher-strength metformin tablet from Pacific Pharmaceuticals Ltd., intended for patients with type 2 diabetes who require a stronger per-tablet dose than 500 mg to reach glycemic targets.

Mechanism of Action

Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves peripheral insulin sensitivity in muscle and adipose tissue, without directly stimulating pancreatic insulin secretion.

Indications

Metfo 850 is indicated for type 2 diabetes mellitus in patients requiring a higher metformin dose, often prescribed after the 500 mg strength has been well tolerated.

Dosage and Administration

A typical regimen is 850 mg once daily with a meal, increasing to twice daily after 1–2 weeks if tolerated, up to a maximum total daily dose generally around 2550 mg.

Contraindications

Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis including diabetic ketoacidosis, and known hypersensitivity to metformin.

Side Effects

Gastrointestinal effects such as nausea, diarrhea, and abdominal discomfort are most common during dose step-up. Long-term use may reduce vitamin B12 absorption.

Drug Interactions

Iodinated contrast media require temporary discontinuation of metformin. Alcohol intake should be limited. Disclose all current medications and supplements to your physician or pharmacist.

Special Precautions

Renal function should be reassessed before stepping up to this higher strength and monitored periodically thereafter.

Storage

Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Frequently Asked Questions

Q1: When is Metfo 850 prescribed instead of Metfo 500?
It is typically prescribed when the 500 mg strength does not provide adequate glycemic control and has been well tolerated.

Q2: Will I need to take Metfo 850 more than once a day?
Many patients begin with once daily and increase to twice daily under physician guidance if needed.

Q3: Does the higher strength cause more stomach upset?
Some patients notice more gastrointestinal discomfort initially; taking it with food helps reduce this.

Q4: Can Metfo 850 be used for long-term maintenance?
Yes, once an effective and well-tolerated dose is established, it is commonly used for long-term therapy.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.