Metfrom ER 500

Metfrom ER 500 — Metformin Hydrochloride (Extended Release, Legacy Listing)

Overview

This is a legacy catalog listing for a 500 mg extended-release metformin tablet. As pack size and current pricing on this older entry may not reflect the latest pharmacy stock, customers are advised to confirm pack size and price with the pharmacy before ordering.

Mechanism of Action

Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves peripheral insulin sensitivity. The extended-release formulation releases the drug gradually, supporting once-daily dosing.

Indications

Indicated for type 2 diabetes mellitus, particularly for patients who prefer once-daily dosing or who experience gastrointestinal side effects with immediate-release metformin.

Dosage and Administration

Usually taken once daily with the evening meal; extended-release tablets must be swallowed whole and never crushed, split, or chewed.

Contraindications

Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis including diabetic ketoacidosis, and known hypersensitivity to metformin.

Side Effects

Generally better gastrointestinal tolerability than immediate-release formulations, though nausea, diarrhea, or abdominal discomfort can still occur. Long-term use may reduce vitamin B12 absorption.

Drug Interactions

Iodinated contrast media require temporary discontinuation of metformin. Alcohol intake should be limited. Disclose all current medications and supplements to your physician or pharmacist.

Special Precautions

Patients may occasionally notice the tablet matrix in stool; this is expected and does not indicate reduced effectiveness. Please verify current pricing and pack size with the pharmacy, as this is a legacy catalog entry.

Storage

Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Frequently Asked Questions

Q1: Is this listing's price up to date?
This is a legacy catalog entry; please confirm current pricing and pack size with the pharmacy before ordering.

Q2: What does "ER" mean in Metfrom ER 500?
ER stands for extended release, meaning the tablet releases medication gradually over time to support once-daily dosing.

Q3: Can I crush Metfrom ER 500 tablets?
No, extended-release tablets must be swallowed whole; ask your pharmacist about alternatives if swallowing is difficult.

Q4: Why might my doctor prescribe the ER formulation instead of immediate-release?
Extended-release formulations offer once-daily convenience and often cause fewer gastrointestinal side effects.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Confirm pack size and current price with the pharmacy before ordering. Dosage and suitability vary by individual health condition.