Nobesit 500mg Tablet

What is Nobesit?

Nobesit is a brand of Metformin Hydrochloride manufactured by Incepta Pharmaceuticals Ltd. It is an immediate-release, first-line oral medication for type 2 diabetes mellitus, widely used to control blood glucose levels, often as initial therapy in newly diagnosed patients.

Generic Name and Composition

Each tablet contains 500 mg of Metformin Hydrochloride.

Indications

• Type 2 diabetes mellitus, particularly in overweight or obese patients, as first-line therapy
• Used alone or in combination with other oral antidiabetic agents or insulin
• May be used in polycystic ovary syndrome (PCOS) under physician guidance

How It Works — Mechanism of Action

Metformin lowers blood glucose primarily by reducing hepatic glucose production, decreasing intestinal absorption of glucose, and improving peripheral insulin sensitivity. It does not stimulate insulin secretion, so it carries a low risk of hypoglycemia when used alone.

Dosage and Administration

• Dosage is individualized by a physician; typically started at a low dose and gradually increased to minimize gastrointestinal side effects.
• Usually taken 2–3 times daily with meals.
• Swallow with a full glass of water; do not crush or chew unless advised.
• Take consistently at the same times each day for best results.

Side Effects

Common: Diarrhea, nausea, vomiting, abdominal discomfort, loss of appetite, metallic taste — usually mild and transient, especially at treatment start.

Uncommon: Vitamin B12 deficiency with long-term use, headache, mild skin reactions.

Rare: Lactic acidosis (more likely with renal impairment, dehydration, or excess alcohol use) — a medical emergency requiring immediate attention.

Drug Interactions

May increase metformin levels / risk of lactic acidosis: Iodinated contrast media, certain medications affecting renal clearance.

May affect blood glucose control: Corticosteroids, diuretics, and some antipsychotics may raise blood glucose; alcohol may increase the risk of lactic acidosis and hypoglycemia.

Other considerations: Inform your doctor about all medications, including herbal supplements, before starting therapy.

Contraindications

• Known hypersensitivity to metformin
• Severe renal impairment
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis
• Conditions predisposing to tissue hypoxia (e.g., severe heart failure, respiratory failure, recent myocardial infarction)
• Severe dehydration, severe infection, or shock

Pregnancy and Lactation

Use during pregnancy and breastfeeding should only be under medical supervision; insulin is often preferred for tight glycemic control in pregnancy. Discuss the risks and benefits with your physician.

Precautions and Warnings

• Temporarily discontinue before procedures using iodinated contrast media, as advised by your physician.
• Use with caution in elderly patients and those with impaired kidney or liver function.
• Monitor renal function periodically during long-term therapy.
• Limit alcohol intake, as it increases the risk of lactic acidosis and hypoglycemia.
• Seek medical attention promptly for symptoms of lactic acidosis: unusual muscle pain, difficulty breathing, stomach discomfort, dizziness, or unusual tiredness.

Overdose

Overdose may lead to lactic acidosis, presenting with severe gastrointestinal symptoms, hypothermia, hypotension, and resistant bradyarrhythmias. This is a medical emergency requiring immediate hospitalization; treatment includes supportive care and hemodialysis to remove metformin and correct acidosis.

Storage Instructions

• Store below 30°C in a dry place, protected from light.
• Keep out of reach of children.
• Do not use after the expiry date printed on the pack.

Frequently Asked Questions

Q1: Why do I need to take Nobesit multiple times a day?
Standard immediate-release metformin is typically dosed 2–3 times daily with meals to maintain steady blood levels and reduce gastrointestinal side effects.

Q2: Why does Nobesit cause stomach upset?
Gastrointestinal side effects are common when starting metformin, especially at higher doses. Taking it with food and gradual dose increases usually help.

Q3: Will Nobesit cause low blood sugar (hypoglycemia)?
Metformin alone rarely causes hypoglycemia since it does not stimulate insulin release. Risk increases if combined with insulin or sulfonylureas.

Q4: How is Nobesit different from Nobesit XR?
Nobesit is an immediate-release tablet typically taken multiple times daily, while Nobesit XR is an extended-release formulation taken once daily with generally better gastrointestinal tolerance.

Medical Disclaimer

This product is available by prescription only (Rx). The information provided is for educational purposes and does not replace professional medical advice. Always consult a registered physician before starting, stopping, or changing any diabetes therapy. DiabetesStore.com.bd is a licensed online pharmacy in Bangladesh.