- Stock: In Stock
- Brand: Incepta Pharmaceuticals
- Product ID: Pyridoxine HCL + Doxylamine Succinate
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Description
Doxylamine is an antihistamine that blocks Histamine (H1) receptor. It affects the vestibular system and decreases the stimulation of the vomiting center. Its mascarinic receptor inhibition may also play a role in antihistamine antiemetic activity. Pyridoxine (Vitamin B6) is a vitamin used to prevent nausea and vomiting due to its antiemetic properties.
Indications
Pyridox tablet is indicated for the treatment of nausea and vomiting of pregnancy in women.
Dosage & Administration
Initially, take one Pyridox tablet orally at bedtime (Day 1). If this dose adequately controls symptoms the next day, continue taking one tablet daily at bedtime only. However, if symptoms persist on Day 2, increase the daily dose to one tablet in the morning and one tablet at bedtime. The maximum recommended dose is two tablets per day, one in the morning and one at bedtime. Take on an empty stomach with a glass of water. Swallow tablets whole. Do not crush, chew, or split Pyridox tablet. Take daily and not on an as needed basis.
Side Effects
Somnolence and falls or other accidents resulting from the effect of the combined use of Pyridox with CNS depressants.
Precautions
Somnolence: Pyridox may cause somnolence due to the anticholinergic properties of doxylamine succinate, an antihistamine. Women should avoid engaging in activities requiring complete mental alertness, such as driving or operating heavy machinery.
Pyridox use is not recommended if a woman is concurrently using central nervous system (CNS) depressants. The combination may result in severe drowsiness leading to falls or accidents. Pyridox has anticholinergic properties and therefore, should be used with caution in women with asthma, increased intraocular pressure, narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction or urinary bladder-neck obstruction.
Use in Pregnancy & Lactation
Pyridox is intended for use in pregnant women.
Drug Interaction
Use of Pyridox is contraindicated in women who are taking monoamine oxidase inhibitors (MAOIs), which prolong and intensify the adverse central nervous system effects (the anticholinergic effects) of antihistamines. Concurrent use of alcohol and other CNS depressants (such as hypnotic sedatives and tranquilizers) with Pyridox is not recommended.
Storage
Store in a cool and dry place away from light.
