- Stock: In Stock
- Brand: Beximco Pharmaceutical
- Product ID: Amoxicillin Trihydrate
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Tycil 500mg Capsule — Amoxicillin Trihydrate 500mg | Beximco Pharmaceuticals
| Generic Name | Amoxicillin Trihydrate 500 mg |
| Dosage Form | Capsule |
| Manufacturer | Beximco Pharmaceuticals Ltd. |
| Therapeutic Class | Aminopenicillin — Broad-Spectrum Beta-Lactam Antibiotic |
| Standard Adult Dose | 500mg three times daily (TDS) for most indications |
| Availability | In Stock — Available Online |
Overview
Tycil 500mg is the standard adult-dose formulation of Beximco's Amoxicillin Trihydrate, containing 500 mg per capsule. Amoxicillin 500mg three times daily (TDS) is the most commonly prescribed oral antibiotic regimen in Bangladesh for a wide range of bacterial infections, including community-acquired respiratory tract infections, urinary tract infections, ear infections, skin infections, and H. pylori eradication. Its excellent oral bioavailability (~93%), broad spectrum, safety profile, and affordability make it a cornerstone of outpatient antimicrobial therapy. The 500mg dose provides higher peak tissue concentrations than 250mg, making it more appropriate for moderate infections or in larger adults.
Key Pharmacokinetic Advantages of Amoxicillin
| Property | Amoxicillin (Tycil) | Ampicillin (comparison) |
|---|---|---|
| Oral bioavailability | ~93% | ~40% (unpredictable) |
| Food effect | None — can take with food | Reduced by food |
| Peak plasma time | 1–2 hours | 1–2 hours (variable) |
| Dosing frequency | TDS (q8h) or BD (q12h at higher doses) | QDS (q6h) |
| Half-life | ~1 hour (adequate for time-dependent killing with TDS) | ~1 hour |
Indications
- Community-Acquired Pneumonia (CAP) — mild, outpatient; S. pneumoniae coverage (combine with macrolide for atypicals)
- Acute Otitis Media — first-line in children and adults; H. influenzae, S. pneumoniae, M. catarrhalis
- Acute Sinusitis — bacterial; 10–14 day course
- Pharyngitis/Tonsillitis — streptococcal; 10-day course to eradicate S. pyogenes and prevent rheumatic fever
- Urinary Tract Infections — uncomplicated (susceptible E. coli, Enterococcus)
- H. pylori Eradication — 1g BD as component of triple therapy (PPI + amoxicillin + clarithromycin)
- Skin & Soft Tissue Infections — streptococcal cellulitis, impetigo
- Dental Infections — abscess, pericoronitis; prophylaxis for endocarditis prevention
- Lyme Disease (early) — 500mg TDS × 14–21 days
Dosage & Administration
| Indication | Dose | Frequency | Duration |
|---|---|---|---|
| Respiratory Infections (CAP, sinusitis) | 500 mg | Three times daily | 7–10 days |
| Otitis Media | 500 mg | Three times daily | 5–10 days |
| Pharyngitis / Tonsillitis | 500 mg | Three times daily | 10 days |
| Uncomplicated UTI | 500 mg | Three times daily | 5–7 days |
| H. pylori Eradication | 1g (2 capsules) | Twice daily | 7–14 days (with PPI + clarithromycin) |
| Skin/Soft Tissue | 500 mg | Three times daily | 7–10 days |
| Dental Prophylaxis | 3g (6 capsules) | Single dose 1 hr pre-procedure | Once |
Take with or without food. At evenly spaced 8-hour intervals. Complete the prescribed course — do not stop early even if symptoms improve.
Special Note for Diabetic Patients
Amoxicillin is highly safe in diabetic patients. No blood glucose effects, no interactions with metformin, insulin, sulfonylureas, SGLT-2 inhibitors, or other diabetes medications. Diabetic patients with UTI (common complication) or respiratory infections can safely use Tycil 500mg. Note: in diabetics with recurrent UTIs or resistant organisms, urine culture and sensitivity is advisable before treating empirically with amoxicillin (resistance rates to amoxicillin vary regionally).
Side Effects
- GI (most common): Diarrhoea (9%), nausea, vomiting — take with food to reduce
- Skin: Non-allergic maculopapular rash (especially with EBV — not a true allergy); urticaria (true allergy, less common)
- Serious: Anaphylaxis (<0.05%); C. difficile colitis (rare)
- Oral/vaginal: Candidiasis (thrush) with prolonged courses — probiotic co-administration may reduce risk
Storage
- Store below 25°C in a dry place, protected from moisture. Keep out of reach of children.
FAQ
Q1: Is amoxicillin effective for COVID-19 or viral infections?
No. Amoxicillin — like all antibiotics — is only effective against bacterial infections, not viruses. It does not treat COVID-19, influenza, common cold, or other viral illnesses. Prescribing antibiotics for viral infections contributes to antibiotic resistance. Use Tycil 500mg only for confirmed or strongly suspected bacterial infections under physician guidance.
Q2: My UTI keeps coming back — can I just take amoxicillin again?
Recurring UTIs should be investigated with urine culture and sensitivity testing before repeating antibiotic treatment. Amoxicillin resistance in E. coli (the most common UTI pathogen) is significant in Bangladesh — empirical retreatment with amoxicillin may fail if the organism is resistant. Your physician may prescribe a different antibiotic based on sensitivity results.
Q3: Can Tycil 500mg be used for H. pylori treatment?
Yes — amoxicillin 1g (2 capsules of 500mg) twice daily is a key component of standard H. pylori triple therapy (PPI + amoxicillin + clarithromycin) for 7–14 days. H. pylori causes peptic ulcers and chronic gastritis. Your gastroenterologist will prescribe the complete regimen.
Medical Disclaimer: Educational information only. Antibiotics require a physician's prescription. Never self-medicate with antibiotics.
