Uliv 300 mg Tablet

Uliv 300 mg Tablet

DESCRIPTION

ULIV (Ursodeoxycholic acid) is used to reduce the cholesterol saturation of bile and to promote the dissolution of gallstones. The cholesterol saturation of bile is reduced by ULIV (Ursodeoxycholic acid), allowing gradual solubilization of cholesterol gallstones.

Cholesterol secretion into bile is reduced and bile acid secretion rate is increased during ULIV (Ursodeoxycholic acid) treatment without a reduction in phospholipids.

COMPOSITION

ULIV 150: Each film-coated tablet contains Ursodeoxycholic acid BP 150 mg.

ULIV 300: Each film-coated tablet contains Ursodeoxycholic acid BP 300 mg.

INDICATIONS

Dissolution of small to medium sized radiolucent, cholesterol rich gallstones in functioning gallbladder, prevention of gallstone formation in obese patients experiencing rapid weight loss, primary biliary cirrhosis.

DOSAGE & ADMINISTRATION

Dissolution of gallstones : 8-12 mg/kg body weight daily as a single dose at bedtime or in two divided doses, for up to 2 years; treatment should be continued for 3-4 months after stones dissolve.

Prevention of gallstone formation : 300 mg twice daily. Primary biliary cirrhoisis: 10-15 mg/kg body weight daily in 2-4 divided doses.

OR AS DIRECTED BY THE PHYSICIAN.

SIDE EFFECTS

Commonly reported side effects are nausea, vomiting, diarrhoea, gallstone calcification, pruritus.

CONTRAINDICATIONS

Contraindicated to pigmented gallstones, non-functioning gall bladder, inflammatory diseases and other conditions of the small intestine, colon and liver which interfere with entero-hepatic circulation of bile salts.

PRECAUTIONS

It should not be used in patients with chronic liver disease, peptic ulcer disease or inflammatory bowel disease. It is ineffective for the dissolution of calcified and pigment gallstones and is of no value in patients without a functioning gallbladder.

USE IN PREGNANCY & LACTATION

There are no adequate and well-controlled studies in pregnant woman. Therefore this drug should be used during pregnancy, if the benefit outweighs the risk. It is not known whether Ursodeoxycholic acid is excreted in human milk. So, caution should be exercised when it is administered to a lactating mother.

DRUG INTERACTIONS

It should not be used with drugs, such as oestrogenic hormones, that increase bile cholesterol. Concomitant administration with bile-acid binding drugs including antacids, charcoal and cholestyramine should be avoided, since this may reduce the effectiveness of therapy with Ursodeoxycholic acid.

SUPPLY

ULIV 150 : Each box contains 2 X 10 tablets in blister strips .

ULIV 300 : Each box contains 1 X 10 tablets in blister strip.