Veracal 40 Tab

What is Veracal?

Veracal (Verapamil Hydrochloride) is an L-type calcium channel blocker manufactured by Incepta Pharmaceuticals Ltd., used for essential hypertension, angina, and supraventricular arrhythmias.

Indications

Essential hypertension, angina pectoris and prevention of re-infarction, supraventricular arrhythmias.

Pharmacology

Verapamil is an L-type calcium channel blocker with antiarrhythmic, antianginal, and antihypertensive activity. It is a negative inotropic agent and should not be used in severe left ventricular dysfunction or hypertrophic cardiomyopathy.

Dosage & Administration

Dose individualized by titration; administer with food. Essential hypertension: 180 mg each morning initially, titrated upward as needed. Angina: 80-120 mg three times daily. Arrhythmias in digitalized patients: 240-360 mg/day in divided doses.

Interaction

Increased plasma levels with CYP3A4 inhibitors (erythromycin, ritonavir), cimetidine; decreased with CYP3A4 inducers (rifampicin), phenobarbital. Increases plasma levels of digoxin, beta-blockers, statins, carbamazepine, and others. Potentiates hypotensive effect of diuretics/antihypertensives.

Contraindications

Severe left ventricular dysfunction, hypotension/cardiogenic shock, sick sinus syndrome, second/third-degree AV block, atrial flutter/fibrillation with accessory pathway (WPW), hypersensitivity to verapamil.

Side Effects

Constipation, nausea, hypotension, edema, bradycardia, AV block, dizziness, headache, fatigue, rash, elevated liver enzymes.

Pregnancy & Lactation

Use only if clearly needed; crosses placenta. Excreted in breast milk — discontinue nursing during use.

Precautions & Warnings

Caution in first-degree AV block, bradycardia, hypotension, atrial fibrillation/flutter with pre-excitation, heart failure. May impair ability to drive; prolongs alcohol effects.

Therapeutic Class

Calcium-channel blockers

Storage Conditions

Do not store above 30°C. Keep away from light and out of reach of children.