Fusid 40 mg Tablet

Overview

Fusid Tablet (Furosemide 40 mg) is a potent loop diuretic used in the management of oedema and hypertension. Furosemide acts on the ascending limb of the loop of Henle by inhibiting the Na⁺-K⁺-2Cl⁻ co-transporter, producing a rapid, dose-dependent diuresis with accompanying excretion of sodium, chloride, potassium, and other electrolytes. It is indicated for oedema associated with congestive heart failure, renal impairment, nephrotic syndrome, and hepatic cirrhosis, as well as mild to moderate hypertension.

Dosage and Administration

Adults — Oedema: Initial dose of 40 mg daily, taken in the morning. The dose may be increased to 80 mg daily or more depending on response. In severe oedema or refractory cases, doses up to 600 mg/day may be required under specialist supervision. Hypertension: 80 mg daily in divided doses, adjusted to response, used in combination with other antihypertensives. Tablets should be taken orally, with or without food. To minimise sleep disturbance from diuresis, do not take late in the day.

Interaction

ACE inhibitors and ARBs may cause profound hypotension when started in patients already on furosemide — temporarily reduce or hold furosemide before initiation. Furosemide elevates serum lithium levels, increasing toxicity risk — monitor levels closely. Combined use with aminoglycosides or cisplatin increases ototoxicity and nephrotoxicity risk. NSAIDs reduce the diuretic response. Furosemide-induced hypokalaemia potentiates digoxin toxicity.

Contraindications

Contraindicated in anuria, states of severe electrolyte depletion (hypokalaemia, hyponatraemia) or hypovolaemia without hypertension, hypersensitivity to furosemide or sulphonamide derivatives, and hepatic pre-coma or coma associated with liver cirrhosis. Caution is required in patients with gout, diabetes, or prostatic enlargement.

Side Effects

Electrolyte disturbances (hypokalaemia, hyponatraemia, hypomagnesaemia) are common, particularly with high doses or prolonged use. Other effects include dehydration, postural hypotension, muscle cramps, hyperuricaemia (with risk of gout), and transient increases in blood glucose. Ototoxicity (tinnitus, hearing impairment) may occur, especially with rapid IV use or high oral doses. Rare: blood dyscrasias, interstitial nephritis, allergic skin reactions.

Pregnancy and Lactation

Furosemide crosses the placenta and is excreted in breast milk. Use during pregnancy only when clearly necessary, avoiding the first trimester where possible. Furosemide inhibits lactation and is present in breast milk; breastfeeding is generally not recommended during treatment. Consult a physician before use.

Precautions and Warnings

Monitor serum electrolytes (particularly potassium), urea, and creatinine regularly, especially in elderly patients, those with renal impairment, or on prolonged high-dose therapy. Potassium supplementation or a potassium-sparing diuretic may be needed. Diabetic patients require closer glucose monitoring as furosemide may impair glucose tolerance. Use with caution in patients with benign prostatic hypertrophy due to risk of urinary retention.

Storage Conditions

Protect from light. Store in a cool, dry place. Keep out of reach of children.

Frequently Asked Questions

Q: When is the best time to take Fusid Tablet?
A: Fusid should be taken in the morning to allow the diuretic effect to occur during the day. If a second dose is needed, take it no later than early afternoon to avoid nighttime urination disrupting sleep.

Q: Do I need to take a potassium supplement with Fusid?
A: Furosemide causes significant urinary potassium loss, which can lead to hypokalaemia. Your physician will advise whether potassium supplementation or a potassium-sparing diuretic is needed based on your serum potassium levels and overall clinical condition. Do not self-supplement without medical guidance.