Sitagil 25mg Tablet

What is Sitagil 25?

Sitagil 25 is a DPP-4 inhibitor (Sitagliptin) manufactured by Incepta Pharmaceuticals Ltd., used to improve blood glucose control in adults with type 2 diabetes mellitus. The 25mg strength is specifically dosed for patients with moderate-to-severe renal impairment, where the standard 100mg dose must be reduced.

Generic Name and Composition

Each tablet contains 25 mg of Sitagliptin (as phosphate monohydrate).

Indications

• Type 2 diabetes mellitus, particularly in patients with renal impairment requiring a reduced sitagliptin dose
• Used as monotherapy or combined with other antidiabetic agents (metformin, sulfonylureas, insulin)
• Used as an adjunct to diet and exercise to improve glycemic control

How It Works — Mechanism of Action

Sitagliptin inhibits the DPP-4 enzyme, which normally breaks down incretin hormones (GLP-1 and GIP). By blocking this enzyme, Sitagil increases active incretin levels, stimulating glucose-dependent insulin release from the pancreas and suppressing glucagon secretion, lowering blood glucose without typically causing hypoglycemia on its own.

Dosage and Administration

• The 25mg dose is typically prescribed for patients with moderate-to-severe chronic kidney disease, as advised by a physician based on creatinine clearance.
• Usual frequency is once daily, with or without food, at the same time each day.
• Swallow the tablet whole with water.
• If a dose is missed, take it as soon as remembered unless it is almost time for the next dose — do not double up.

Side Effects

Common: Upper respiratory tract infection, nasopharyngitis, headache.

Uncommon: Hypoglycemia (mainly when combined with sulfonylureas or insulin), nausea.

Rare: Pancreatitis, severe allergic reactions (angioedema, urticaria, anaphylaxis), bullous pemphigoid (severe skin blistering), worsening renal function.

Drug Interactions

Increased hypoglycemia risk: Sulfonylureas, insulin.

Other considerations: Digoxin levels may be slightly increased with concurrent use, though usually not clinically significant; inform your doctor of all medicines you are taking, especially if you have kidney disease.

Contraindications

• Known hypersensitivity to sitagliptin or any excipient
• History of serious hypersensitivity reaction to any DPP-4 inhibitor

Pregnancy and Lactation

Safety in pregnancy and breastfeeding has not been firmly established; insulin is generally preferred for glycemic control during pregnancy. Consult a physician before use if pregnant, planning pregnancy, or breastfeeding.

Precautions and Warnings

• Dose must be adjusted based on kidney function — do not change strength without physician guidance, as renal function determines the correct dose.
• Watch for symptoms of pancreatitis (persistent severe abdominal pain) and discontinue promptly if suspected, seeking medical attention.
• Discontinue if signs of severe skin blistering (bullous pemphigoid) occur and consult a dermatologist or physician.
• Use with caution when combined with sulfonylureas or insulin due to increased hypoglycemia risk.
• Periodic renal function monitoring is recommended, especially in patients with pre-existing kidney impairment.

Overdose

Sitagliptin has a wide safety margin and overdose is unlikely to cause significant hypoglycemia on its own. In case of suspected overdose, seek medical attention; supportive treatment, including hemodialysis if needed for severe renal cases, may be considered.

Storage Instructions

• Store below 30°C in a cool, dry place, away from direct sunlight and moisture.
• Keep out of reach of children.
• Do not use after the expiry date printed on the pack.

Frequently Asked Questions

Q1: Why is Sitagil available in a 25mg strength?
The 25mg dose is specifically for patients with moderate-to-severe kidney impairment, who require a lower sitagliptin dose than the standard 100mg used in patients with normal kidney function.

Q2: Can I switch between Sitagil strengths on my own?
No — strength selection depends on kidney function and must be determined by your physician based on laboratory tests.

Q3: Will Sitagil cause low blood sugar on its own?
Sitagil alone has a low risk of hypoglycemia since it works in a glucose-dependent manner; risk increases when combined with sulfonylureas or insulin.

Q4: How does Sitagil 25mg compare to Sitagil 50mg?
Both contain the same sitagliptin, but at different strengths; the 25mg dose is reserved for more severe renal impairment, while 50mg is used for milder kidney impairment, with dosing determined by your physician.

Medical Disclaimer

This product is available by prescription only (Rx) and should be used under medical supervision. The information provided is for educational purposes and does not replace professional medical advice. Always consult a registered physician before starting, stopping, or changing any medication. DiabetesStore.com.bd is a licensed online pharmacy in Bangladesh.