- Stock: In Stock
- Brand: Beximco Pharmaceutical
- Product ID: Amlodipine + Atenolol
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Amdocal PLUS 50 Tablet — Amlodipine 5mg + Atenolol 50mg | Beximco Pharmaceuticals
| Generic Names | Amlodipine Besilate 5 mg + Atenolol 50 mg |
| Dosage Form | Film-Coated Tablet |
| Manufacturer | Beximco Pharmaceuticals Ltd. |
| Therapeutic Class | Fixed-Dose Combination Antihypertensive (CCB + Beta-Blocker) |
| Pack Size | 30 Tablets per Box |
| Availability | In Stock — Available Online |
Overview
Amdocal PLUS 50 Tablet is the higher-strength fixed-dose combination antihypertensive from Beximco Pharmaceuticals Ltd., containing Amlodipine Besilate 5 mg and Atenolol 50 mg. It provides double the atenolol dose of Amdocal PLUS 25, making it appropriate for patients requiring more pronounced heart rate reduction — including those with hypertension plus significant tachycardia, stable angina with inadequate control, or post-MI patients needing cardioprotective beta-blocker doses.
Indications
- Hypertension + Tachycardia — stronger heart rate control alongside BP reduction
- Hypertension + Stable Angina — full 50 mg atenolol dose for superior anti-ischaemic effect
- Post-MI Hypertension — standard cardioprotective atenolol dose plus vasodilation
- Hypertension Inadequately Controlled on Amdocal PLUS 25 — step-up therapy
Benefits
- Full standard atenolol dose (50 mg) + amlodipine 5 mg in one daily tablet
- Stronger heart rate reduction than Amdocal PLUS 25
- Single once-daily tablet improves adherence
- Amlodipine counteracts peripheral vasoconstriction from atenolol
- Manufactured under WHO-GMP standards by Beximco Pharmaceuticals
Pharmacology
Amlodipine (5 mg): Long-acting dihydropyridine CCB. Selectively inhibits L-type calcium channels in vascular smooth muscle, causing arteriolar vasodilation, reducing peripheral resistance and BP. Half-life 35–50 hours.
Atenolol (50 mg): Cardioselective beta-1 blocker at standard therapeutic dose. At 50 mg, produces significant reduction in resting and exercise heart rate, myocardial contractility, cardiac output, and renin release. The 50 mg dose achieves near-complete beta-1 blockade at rest in most adults. Half-life 6–9 hours; renally eliminated.
Dosage & Administration
| Indication | Dose | Notes |
|---|---|---|
| Hypertension / Angina | 1 tablet once daily | Same time each day; with or without food |
| Renal Impairment (eGFR 15–35) | Every 48 hours | As directed by physician |
| Severe Renal Impairment (eGFR <15) | Every 96 hours | Specialist supervision required |
Important: Never stop abruptly — taper atenolol gradually to avoid rebound angina or hypertensive crisis.
Special Populations
- Diabetic Patients: Atenolol 50 mg strongly blunts hypoglycaemia tachycardia warning. Frequent glucose monitoring essential.
- Elderly: Increased risk of bradycardia and falls. Start with Amdocal PLUS 25.
- Renal Impairment: Atenolol accumulates in CKD — extend dosing interval. Amlodipine needs no renal adjustment.
- Pregnancy: Avoid — atenolol is Category D (fetal growth restriction).
Contraindications
- Bradycardia (HR <50 bpm), sick sinus syndrome, 2nd/3rd degree AV block
- Cardiogenic shock or decompensated heart failure
- Severe hypotension (systolic <90 mmHg)
- Significant asthma/COPD
- Hypersensitivity to amlodipine or atenolol
Key Drug Interactions
| Drug | Interaction |
|---|---|
| Verapamil / Diltiazem | Severe bradycardia and AV block risk. Avoid. |
| Insulin / Sulfonylureas | Atenolol masks hypoglycaemia tachycardia — monitor glucose closely. |
| Clonidine | Rebound hypertension on clonidine withdrawal — taper clonidine first. |
| NSAIDs | Reduce antihypertensive effect of both components. |
| CYP3A4 Inhibitors | May increase amlodipine exposure; monitor for hypotension. |
Side Effects
Common: Fatigue, bradycardia, cold extremities, peripheral oedema, dizziness, flushing.
Uncommon: Nausea, nightmares, depression, bronchospasm (susceptible patients), insomnia.
Rare: AV block, severe hypotension, Raynaud's phenomenon, psoriasiform rash.
Storage
- Store below 30°C, protect from moisture and sunlight
- Keep in original blister pack; keep out of reach of children
Frequently Asked Questions
Q1: What is Amdocal PLUS 50 used for?
It treats hypertension and angina where stronger heart rate control is needed than Amdocal PLUS 25 provides. Also used in post-MI patients requiring standard cardioprotective atenolol doses (50 mg).
Q2: How is it different from Amdocal PLUS 25?
Both contain amlodipine 5 mg. Amdocal PLUS 50 has atenolol 50 mg vs 25 mg — providing stronger heart rate reduction and beta-blockade, suitable for faster resting HRs or more severe angina.
Q3: Can diabetic patients take Amdocal PLUS 50?
With caution. Atenolol 50 mg significantly blunts the tachycardia warning of hypoglycaemia. Patients on insulin or sulfonylureas must monitor glucose more frequently and discuss with their physician.
Q4: Can I stop it abruptly?
Never. Sudden withdrawal of atenolol can trigger rebound angina, MI, or hypertensive crisis. Taper gradually under physician guidance over 1–2 weeks.
Q5: Safe for asthma/COPD patients?
No. Even at 50 mg, atenolol may trigger bronchospasm in significant airway disease. Discuss safer alternatives with your physician.
Q6: Is it prescription-only?
Yes — Rx medicine. Upload your prescription when ordering from DiabetesStore.com.bd.
Medical Disclaimer: Educational purposes only. Always consult a registered physician or pharmacist before starting, changing, or stopping any medication. DiabetesStore.com.bd is not liable for outcomes from this information.
