Oxecylin 250 mg Capsule

Oxecylin 250 mg Capsule

Indications

Acne vulgaris, Gluten enteropathy or sprue, Gnathostomiasis, Gonorrhoea, Superficial ophthalmic infections, Susceptible infections, Uncomplicated gonorrhoea

Pharmacology

Oxytetracycline binds reversibly to the 30S and possibly 50S ribosomal subunits, thus inhibiting bacterial protein synthesis and arresting cell growth. It is active against a wide range of gram-positive and gram-negative organisms.

Dosage

Intramuscular:

Susceptible infections:

Adult: 250 mg once daily or 300 mg daily in 2-3 divided doses.

Child: >8 yr: 15-25 mg/kg (max 250 mg) daily in 2-3 divided doses.

Oral:

Susceptible infections:

Adult: 250-500 mg 4 times daily. Max 4 g daily.

Child: >8 yr: 25-50 mg/kg daily in 4 divided doses.

Acne:

Adult: 250-500 mg bid.

Unco-mplicated gonorrhoea:

Adult: 1.5 g initially, followed by 0.5 g four times daily up to a total of 9 g per treatment course.

Administration

Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals.

Interaction

Antacids, iron, aluminum, calcium, magnesium, zinc salts reduce absorption. Concurrent use may cause increased levels of lithium, digoxin, halofantrine and theophylline; decreased concentrations of atovaquone. Increased risk of ergotism with ergot alkaloids. May cause failure of oral contraception

Contraindications

Hypersensitivity to tetracyclines, children <8 yr, renal damage. Pregnancy, lactation.

Side Effects

Anorexia, nausea, vomiting,diarrhoea, glossitis, dysphagia, photosensitivity, oesphageal irritation and ulceration, nephrotoxicity, enterocolitis, rash (rare), blood dyscrasias. Headache, visual disturbances; intracranial hypertension; bulging fontanelles (infants).

Pregnancy & Lactation

Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).