- Stock: In Stock
- Brand: Acme Laboratories Limited
- Product ID: Oxytetracycline
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Oxecylin 250 mg Capsule
Indications
Acne vulgaris, Gluten enteropathy or sprue, Gnathostomiasis, Gonorrhoea, Superficial ophthalmic infections, Susceptible infections, Uncomplicated gonorrhoea
Pharmacology
Oxytetracycline binds reversibly to the 30S and possibly 50S ribosomal subunits, thus inhibiting bacterial protein synthesis and arresting cell growth. It is active against a wide range of gram-positive and gram-negative organisms.
Dosage
Intramuscular:
Susceptible infections:
Adult: 250 mg once daily or 300 mg daily in 2-3 divided doses.
Child: >8 yr: 15-25 mg/kg (max 250 mg) daily in 2-3 divided doses.
Oral:
Susceptible infections:
Adult: 250-500 mg 4 times daily. Max 4 g daily.
Child: >8 yr: 25-50 mg/kg daily in 4 divided doses.
Acne:
Adult: 250-500 mg bid.
Unco-mplicated gonorrhoea:
Adult: 1.5 g initially, followed by 0.5 g four times daily up to a total of 9 g per treatment course.
Administration
Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals.
Interaction
Antacids, iron, aluminum, calcium, magnesium, zinc salts reduce absorption. Concurrent use may cause increased levels of lithium, digoxin, halofantrine and theophylline; decreased concentrations of atovaquone. Increased risk of ergotism with ergot alkaloids. May cause failure of oral contraception
Contraindications
Hypersensitivity to tetracyclines, children <8 yr, renal damage. Pregnancy, lactation.
Side Effects
Anorexia, nausea, vomiting,diarrhoea, glossitis, dysphagia, photosensitivity, oesphageal irritation and ulceration, nephrotoxicity, enterocolitis, rash (rare), blood dyscrasias. Headache, visual disturbances; intracranial hypertension; bulging fontanelles (infants).
Pregnancy & Lactation
Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).