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- Product ID: Humalog Mix 75/25 KwikPen
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Humalog Mix 75/25 KwikPen – Insulin Lispro Protamine/Lispro by Eli Lilly
| Generic Name | Insulin Lispro Protamine / Insulin Lispro (75/25) |
| Brand Name | Humalog Mix 75/25 |
| Manufacturer | Eli Lilly and Company (USA) |
| Dosage Form | Suspension for Injection — Pre-filled KwikPen (3 ml) |
| Strength | 100 IU/ml (75% intermediate + 25% rapid-acting) |
| Pack Size | 5 KwikPens × 3 ml = 1,500 IU total |
| Drug Class | Premixed Insulin Analogue (Biphasic, 75/25) |
| Prescription Required | Yes — Rx Only |
| Onset / Peak / Duration | Onset: 15 min | Peak: 30 min–2.5 hrs | Duration: ~22 hrs |
What is Humalog Mix 75/25 KwikPen?
Humalog Mix 75/25 KwikPen is a premixed biphasic insulin analogue by Eli Lilly combining 75% insulin lispro protamine (intermediate-acting) and 25% insulin lispro (rapid-acting). The 75/25 ratio provides more intermediate-acting coverage than Mix 50/50, suited to patients with higher basal insulin requirements relative to mealtime needs. Covers both mealtime and basal needs in a single twice-daily injection. KwikPen delivers 1-unit steps up to 60 IU per injection.
Generic Name & Composition
Each ml: 75 IU insulin lispro protamine crystals (intermediate, ~22 hrs duration) + 25 IU soluble insulin lispro (rapid, onset 15 min, peak 30–90 min). Protamine crystals provide sustained basal coverage; soluble lispro controls post-meal glucose. Suspension — must be resuspended before each injection.
Indications
- Type 2 diabetes mellitus — twice-daily premixed analogue regimen
- Patients requiring more intermediate-acting coverage relative to rapid (75/25 vs 50/50)
- Transitioning from premixed human insulins to premixed analogues
- Fixed meal schedule with standard meals and minimal post-meal glucose spikes
How It Works — Mechanism of Action
The soluble lispro (25%): rapid onset 15 min, peak 30 min–2.5 hrs — controls post-meal glucose. The lispro protamine (75%): dissolves slowly over ~22 hrs — provides prolonged basal coverage. Both activate insulin receptors: GLUT-4 glucose uptake, hepatic glucose suppression, glycogen synthesis.
Dosage & Administration
Regimen: Twice daily within 15 minutes before or immediately after breakfast and dinner. KwikPen: Roll 10×, invert 10× until milky-white suspension is uniform. Dial dose, inject subcutaneously, hold 5 seconds. Rotate injection sites.
Side Effects
Very common: Hypoglycaemia — higher risk if meal is delayed.
Common: Injection site reactions, lipohypertrophy, weight gain.
Uncommon: Lipoatrophy, peripheral oedema.
Rare: Anaphylaxis, severe allergic reactions.
Drug Interactions
Increase hypoglycaemia: Sulphonylureas, GLP-1 agonists, SGLT-2 inhibitors, ACE inhibitors, MAO inhibitors, salicylates, alcohol.
Reduce effect: Corticosteroids, glucagon, thyroid hormones, thiazides, sympathomimetics.
Caution: Beta-blockers mask hypoglycaemia symptoms.
Contraindications
- Hypersensitivity to insulin lispro, protamine, or any excipient
- Active hypoglycaemia; subcutaneous use only
Pregnancy & Lactation
Pregnancy: May be used under specialist supervision; dose requirements change during gestation. Lactation: Not expected in breast milk at significant concentrations.
Precautions & Warnings
- Resuspend before every injection — roll 10×, invert 10×. Incomplete resuspension delivers wrong 75/25 ratio.
- Eat within 15 minutes of injection.
- 75% intermediate component: May cause morning hypoglycaemia if dinner dose is too high.
Overdose
Hypoglycaemia. Extended risk from intermediate component. Mild: oral glucose. Severe: IV dextrose or IM glucagon.
Storage Instructions
- Unopened: 2–8°C. Do not freeze.
- In-use pen: Below 30°C. Do not refrigerate.
- Discard 28 days after first use.
Frequently Asked Questions (FAQs)
Q1: What is the difference between Mix 75/25 and Mix 50/50?
Mix 75/25: 75% intermediate + 25% rapid — more background basal coverage, lower post-meal coverage. Mix 50/50: equal components — stronger post-meal coverage. Your diabetologist determines which suits your glucose pattern.
Q2: How is Humalog Mix 75/25 different from NovoMix 30?
NovoMix 30 has 30% rapid aspart vs Mix 75/25 with 25% rapid lispro. Both are biphasic premixed analogues. Clinical choice depends on patient response and local availability.
Q3: Must Humalog Mix 75/25 be resuspended before every injection?
Yes — every time without exception. Roll 10×, invert 10×. Skipping delivers an inaccurate insulin ratio.
Q4: Who manufactures Humalog Mix 75/25?
Eli Lilly and Company (Indianapolis, USA).
⚕ Medical Disclaimer: For educational purposes only. Humalog Mix 75/25 is Rx-only. Consult your diabetologist before changing insulin therapy. DiabetesStore.com.bd is a licensed online pharmacy.
