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Fenatrol 145

Fenatrol 145, ,
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Fenatrol 145
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Introduction

Fenatrol 145 is a medicine used to treat high cholesterol. This medicine helps by lowering triglycerides and "bad" cholesterol (LDL), while at the same time raising the levels of "good" cholesterol (HDL). Lowering cholesterol levels reduces the risk of heart attack and stroke. Fenatrol 145 should be taken in the dose and duration as advised by the doctor. You can take it at any time of day with food but try to take it at the same time each day. Most people with high cholesterol do not feel ill, but if you stop taking this medicine, your condition could get worse. This may lead to your cholesterol levels rising up again and increase your risk of heart disease and stroke. It is important to have your cholesterol levels checked regularly. This medicine is only one part of a treatment program which should also include a healthy diet, regular exercise, smoking cessation, moderation of alcohol intake and weight reduction. You can eat normally while taking this medicine, but try to avoid foods that are high in fat. Common side effects of this medicine include nausea, abdominal pain, diarrhea, and vomiting. Before taking this medicine it is better to let your doctor know about all the other medicines that are prescribed to you. This medicine should be taken with caution if you are suffering from any kidney or liver disease. Also, pregnant women and breastfeeding mothers should not take this medicine without consulting the doctor.

Uses of Fenatrol 145

  • High triglycerides
  • High cholesterol

Side effects of Fenatrol 145

Common
  • Increased liver enzymes
  • Nausea
  • Vomiting
  • Flatulence
  • Abdominal pain
  • Diarrhea

How to use Fenatrol 145

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Fenatrol 145 is to be taken empty stomach.

How Fenatrol 145 works

Fenatrol 145 is a lipid lowering medication. It works by lowering the levels of triglycerides and "bad" cholesterol (LDL), while raising the levels of "good" cholesterol (HDL).

What if you forget to take Fenatrol 145?

If you miss a dose of Fenatrol 145, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

quick tipsQuick Tips
  • It should be taken with food.
  • Avoid alcohol consumption while taking this medication.
  • Your doctor may check your liver function before starting treatment and regularly thereafter. Notify your doctor if you are more tired than usual, do not feel hungry, or if you have yellow eyes, skin or dark urine.
  • Inform your doctor if you experience muscle pain, tenderness, cramps, or weakness while taking Fenatrol 145, particularly if it is accompanied by a fever.
  • Do not discontinue Fenatrol 145 without consulting your doctor even if you feel better.
descriptionBrief Description

Indication

Hyperlipidemia, Hypercholesterolaemia, Hypertriglyceridaemia

Administration

Should be taken with food.

Adult Dose

Oral Hypercholesterolemia, Mixed dyslipidemia, Hypertriglyceridemia Tablet: 40-160mg once daily. Capsule: 200mg once daily. Hepatic impairment: Contraindicated.

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment Mild-Moderate: Initial: lower dose Severe: contraindicated

Contraindication

Hypersensitivity; severe hepatic and renal impairment. Unexplained persistent liver function abnormality and primary biliary cirrhosis; preexisting gall bladder disease. Pregnancy, lactation.

Mode of Action

Fenofibrate, a fibric acid derivative, lowers plasma triglyceride by activating lipoprotein lipase thus increasing catabolism of VLDL w/ consequent increase in HDL levels.

Precaution

Renal or hepatic impairment. Monitor LFTs and blood counts regularly. Increased risk of cholelithiasis, pancreatitis, skeletal muscle effects. Withdraw treatment if no adequate response after 2 mth of treatment at max recommended dose. Lactation: Unknown if excreted in breast milk; not recommended

Side Effect

1-10% Abdominal pain (4.6%),Back pain (3.4%),Increased AST (3.4%),Headache (3.2%),Increased ALT (3%),Increased CPK (3%),Nausea (2.3%),Constipation (2.1%) Potentially Fatal: Hepatitis, cholecystitis.

Pregnancy Category Note

Pregnancy Limited available data with fenofibrate use in pregnant women are insufficient to determine a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes Animal data In animal reproduction studies, no evidence of embryo-fetal toxicity was observed with oral administration in rats and rabbits during organogenesis at doses less than or equivalent to the maximum recommended clinical dose of 120 mg daily, based on body surface area (mg/m2) Adverse reproductive outcomes occurred at higher doses in presence of maternal toxicity; drug should be used during pregnancy only if potential benefit justifies potential risk to fetus Lactation There is no available information on presence of drug in human milk, effects on the breastfed infant, or on milk production; drug is present in milk of rats, and likely to be present in human milk; because of potential for serious adverse reactions in breastfed infants, such as disruption of infant lipid metabolism, women should not breastfeed during treatment and for 5 days after final dose

Interaction

Decreased absorption w/ bile acid sequestrants (e.g. colestyramine). May increase risk of ciclosporin-induced nephrotoxicity. Increased risk of muscle toxicity w/ HMG-CoA reductase inhibitors (e.g. simvastatin). May increase risk of bleeding w/ oral anticoagulants.

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