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Amdocal 10 Tab
Amdocal 10 Tab1. What Amdocal is and what it is used for?Amdocal® (Amlodipine) is a dihydropyridine calcium antagonist, with a long duration of action, used for the treatment of hypertension and angina pectoris.2. Before you take AmdocalDo not take this medicine and tell your doctor if:Amlodipine is contraindicated in patients with known hypersensitivity to Amlodipine.Do not take this medicine if the above applies to you. If you are not sure, talk to your doctor before taking Amdocal.Take special care with AmdocalCaution should be exercised when administering Amlodipine with any other peripheral vasodilator particularly in patients with severe aortic stenosis. Although haemodynamic studies and a controlled trial in Class-II-III heart failure patients have shown that Amlodipine did not lead to clinical deterioration as measured by exercise tolerance, left ventricular ejection fraction and clinical symptomatology in general, all calcium channel blockers should be used with caution in patients with heart failure.Amlodipine gives no protection against the danger of abrupt beta-blocker withdrawal; any such withdrawal should be gradual reduction of the dose of beta-blocker. Since Amlodipine is extensively metabolized by the liver, so caution should be exercised when administering Amlodipine to patients with hepatic impairment.Taking other medicinesNo significant drug interactionPregnancy and breast-feedingNo relevant data is available.How to take Amdocal?The usual initial antihypertensive oral dose is 5mg once daily with a maximum dose of 10 mg once daily. Elderly individuals or patients with hepatic insufficiency may be started with 2.5 mg once daily dose and this dose may be used when adding Amdocal® to other antihypertensive therapy.Dosage should be adjusted according to each patient′s need.The recommended dose for stable or vasospastic angina is 5-10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency.Always use Amdocal exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.If you take more Amdocal than you shouldIn humans, experience with intentional overdosage of Amlodipine is limited. If massive overdosage occurs, active cardiac and respiratory monitoring should be instituted. Frequent blood pressure measurements are essential.If you forget to take AmdocalIf you forget to take a dose, take it as soon as you remember it. However, if it is nearly time for the next dose, skip the missed dose. Do not take a double dose to make up for a forgotten doseIf you stop taking AmdocalDo not stop taking this medicine without talking to your doctor. You should not stop taking Amdocal just because you feel better. This is because the problem may come back or get worse again.If you have any further questions on the use of this product, ask your doctor or pharmacist.3. Possible side effectsLike all medicines, Amdocal can cause side effects, although not everybody gets them.Peripheral oedema may occasionally be severe but is fully reversible. As with other calcium antagonist drugs, peripheral oedema and skin erythema occur in a proportion of patients (5-10%) and facial flushing in 2-5% of patients. Complaint of fatigue was also reported more frequently than in placebo-treated patients.There is evidence that these effects are more common in patients treated with doses greater than 10 mg daily.Tell your doctor if any of the side effects gets serious or lasts longer than a few days, or if you notice any side effects not listed in this leaflet4. How to store AmdocalStore below 25°C. Protect from light. Keep out of reach of children...
Tk.7.00/=
Amdocal 5 Tablet
Amdocal 5 Tablet1. What Amdocal is and what it is used for?Amdocal® (Amlodipine) is a dihydropyridine calcium antagonist, with a long duration of action, used for the treatment of hypertension and angina pectoris.2. Before you take AmdocalDo not take this medicine and tell your doctor if:Amlodipine is contraindicated in patients with known hypersensitivity to Amlodipine.Do not take this medicine if the above applies to you. If you are not sure, talk to your doctor before taking Amdocal.Take special care with AmdocalCaution should be exercised when administering Amlodipine with any other peripheral vasodilator particularly in patients with severe aortic stenosis. Although haemodynamic studies and a controlled trial in Class-II-III heart failure patients have shown that Amlodipine did not lead to clinical deterioration as measured by exercise tolerance, left ventricular ejection fraction and clinical symptomatology in general, all calcium channel blockers should be used with caution in patients with heart failure.Amlodipine gives no protection against the danger of abrupt beta-blocker withdrawal; any such withdrawal should be gradual reduction of the dose of beta-blocker. Since Amlodipine is extensively metabolized by the liver, so caution should be exercised when administering Amlodipine to patients with hepatic impairment.Taking other medicinesNo significant drug interactionPregnancy and breast-feedingNo relevant data is available.How to take Amdocal?The usual initial antihypertensive oral dose is 5mg once daily with a maximum dose of 10 mg once daily. Elderly individuals or patients with hepatic insufficiency may be started with 2.5 mg once daily dose and this dose may be used when adding Amdocal® to other antihypertensive therapy.Dosage should be adjusted according to each patient′s need.The recommended dose for stable or vasospastic angina is 5-10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency.Always use Amdocal exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.If you take more Amdocal than you shouldIn humans, experience with intentional overdosage of Amlodipine is limited. If massive overdosage occurs, active cardiac and respiratory monitoring should be instituted. Frequent blood pressure measurements are essential.If you forget to take AmdocalIf you forget to take a dose, take it as soon as you remember it. However, if it is nearly time for the next dose, skip the missed dose. Do not take a double dose to make up for a forgotten doseIf you stop taking AmdocalDo not stop taking this medicine without talking to your doctor. You should not stop taking Amdocal just because you feel better. This is because the problem may come back or get worse again.If you have any further questions on the use of this product, ask your doctor or pharmacist.3. Possible side effectsLike all medicines, Amdocal can cause side effects, although not everybody gets them.Peripheral oedema may occasionally be severe but is fully reversible. As with other calcium antagonist drugs, peripheral oedema and skin erythema occur in a proportion of patients (5-10%) and facial flushing in 2-5% of patients. Complaint of fatigue was also reported more frequently than in placebo-treated patients.There is evidence that these effects are more common in patients treated with doses greater than 10 mg daily.Tell your doctor if any of the side effects gets serious or lasts longer than a few days, or if you notice any side effects not listed in this leaflet4. How to store AmdocalStore below 25°C. Protect from light. Keep out of reach of children...
Tk.5.50/=
Amdocal PLUS 25 Tablet
Amdocal PLUS 25 Tablet1. What Amdocal Plus is and what it is used for?Amdocal Plus® is a fixed dose combination of Amlodipine Besilate and Atenolol. Amlodipine Besilate is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Atenolol is (2-Hydroxy-3-isopropyl- aminopropoxy) phenylacetamide, a selective b1 blocker. Amdocal Plus used in the treatment of Hypertension not controlled by monotherapy, Angina pectoris & hypertension co-existing diseases, Post M.I patients. Refractory angina pectoris where nitrate therapy has failed.2. Before you take Amdocal PlusDo not take this medicine and tell your doctor if:Amlodipine is contraindicated in patients with a known sensitivity to dihydropyridines. It should not be used in cardiogenic shock, clinically significant aortic stenosis, unstable angina (excluding Prinzmetal’s angina). Atenolol is contraindicated with a known hypersensitivity to Atenolol, severe bradycardia, second degree or the third degree heart block, uncontrolled heart failure, hypotension, severe peripheral vascular disease (including intermittent claudication), sick sinus syndrome, cardiogenic shock, phaeocromocytoma (without a concommitant alpha blocker), metabolic acidosis. Do not take this medicine if the above applies to you. If you are not sure, talk to your doctor before taking Amdocal Plus.Take special care with Amdocal PlusAtenolol may mask the symptoms of hyperthyroidism. It may also mask the symptoms of hypoglycaemia, as well as enhancing the effects of hypoglycemic agents in patients with diabetes mellitus.Taking other medicinesAtenolol: The effects of other myocardial depressant agents, including anti-arrhythmics such as Quinidine, Procainamide, or Lignocaine, Phenytoin, and medicines which interfere with calcium transport, such as Verapamil, may also be enhanced by Atenolol.The effects of Atenolol are diminished by beta-adrenoceptor stimulating agents such as Isoprenaline; the hypotensive effects of Atenolol may be dangerously reversed and the peripheral vasoconstrictor effects enhanced by alpha-adrenoceptor stimulating agents such as noradrenaline or those with mixed alpha- and beta-adrenoceptor stimulating properties such as adrenaline; bradycardia may also occur.The effects of Atenolol may be enhanced by adrenergic neuron blocking agents such as Guanethidine or Bethanidine, or Catecholamine-depleting agents such as Reserpine and the hypotensive effects by diuretics. Atenolol may enhance some of the cardiac effects of digitalis and diminish others. It has been suggested that clonidine withdrawal symptoms may be exacerbated in patients who are concurrently taking a beta blocker.Pregnancy and breast-feedingAtenolol crosses the placenta. So it is contraindicated in pregnancy and lactation.3. How to take Amdocal Plus?The recommended dosage is one tablet of Amdocal Plus® 50 (Amlodipine 5mg and Atenolol 50mg) or Amdocal Plus® 25 (Amlodipine 5mg and Atenolol 25 mg). Depending upon the therapeutic response, titration of the dosage is recommended. In elderly patients, it is advisable to initiate the therapy with 1/2 tablet of fixed dose combination of Amlodipine & Atenolol i.e. 2.5 mg Amlodipine & 25 mg Atenolol.If you take more Amdocal Plus than you shouldIn humans, experience with intentional overdosage of Amlodipine is limited. If massive overdosage occurs, active cardiac and respiratory monitoring should be instituted. Frequent blood pressure measurements are essential.If you forget to take Amdocal PlusIf you forget to take a dose, take it as soon as you remember it. However, if it is nearly time for the next dose, skip the missed dose. Do not take a double dose to make up for a forgotten doseIf you stop taking Amdocal PlusDo not stop taking this medicine without talking to your doctor. You should not stop taking Amdocal Plus just because you feel better. This is because the problem may come back or get worse again.If you have any further questions on the use of this product, ask your doctor or pharmacist.4. Possible side effectsLike all medicines, Amdocal Plus can cause side effects, although not everybody gets them.Amlodipine: Peripheral edema may occasionally be present but is fully reversible. As with other calcium channel blockers peripheral edema and skin erythema occur in a proportion of patients and facial flushing occurs in 2-5% of patients. Complaints of fatigue were also reported more frequently than in placebo-treated patients. There is evidence that these effects are more common in patients treated with doses greater than 10 mg daily.Atenolol: Pronounced fatigue and cold extremities have been observed in 10 to 20% of the treated subjects. Complaints about bradycardia, dizziness and gastrointestinal symptoms are less frequent. Despite its relative selectivity, Atenolol can cause bronchospasms in asthma patients.Tell your doctor if any of the side effects gets serious..
Tk.5.25/=
Amdocal PLUS 50 Tablet
Amdocal PLUS 50 Tablet1. What Amdocal Plus is and what it is used for?Amdocal Plus® is a fixed dose combination of Amlodipine Besilate and Atenolol. Amlodipine Besilate is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Atenolol is (2-Hydroxy-3-isopropyl- aminopropoxy) phenylacetamide, a selective b1 blocker. Amdocal Plus used in the treatment of Hypertension not controlled by monotherapy, Angina pectoris & hypertension co-existing diseases, Post M.I patients. Refractory angina pectoris where nitrate therapy has failed.2. Before you take Amdocal PlusDo not take this medicine and tell your doctor if:Amlodipine is contraindicated in patients with a known sensitivity to dihydropyridines. It should not be used in cardiogenic shock, clinically significant aortic stenosis, unstable angina (excluding Prinzmetal’s angina). Atenolol is contraindicated with a known hypersensitivity to Atenolol, severe bradycardia, second degree or the third degree heart block, uncontrolled heart failure, hypotension, severe peripheral vascular disease (including intermittent claudication), sick sinus syndrome, cardiogenic shock, phaeocromocytoma (without a concommitant alpha blocker), metabolic acidosis. Do not take this medicine if the above applies to you. If you are not sure, talk to your doctor before taking Amdocal Plus.Take special care with Amdocal PlusAtenolol may mask the symptoms of hyperthyroidism. It may also mask the symptoms of hypoglycaemia, as well as enhancing the effects of hypoglycemic agents in patients with diabetes mellitus.Taking other medicinesAtenolol: The effects of other myocardial depressant agents, including anti-arrhythmics such as Quinidine, Procainamide, or Lignocaine, Phenytoin, and medicines which interfere with calcium transport, such as Verapamil, may also be enhanced by Atenolol.The effects of Atenolol are diminished by beta-adrenoceptor stimulating agents such as Isoprenaline; the hypotensive effects of Atenolol may be dangerously reversed and the peripheral vasoconstrictor effects enhanced by alpha-adrenoceptor stimulating agents such as noradrenaline or those with mixed alpha- and beta-adrenoceptor stimulating properties such as adrenaline; bradycardia may also occur.The effects of Atenolol may be enhanced by adrenergic neuron blocking agents such as Guanethidine or Bethanidine, or Catecholamine-depleting agents such as Reserpine and the hypotensive effects by diuretics. Atenolol may enhance some of the cardiac effects of digitalis and diminish others. It has been suggested that clonidine withdrawal symptoms may be exacerbated in patients who are concurrently taking a beta blocker.Pregnancy and breast-feedingAtenolol crosses the placenta. So it is contraindicated in pregnancy and lactation.3. How to take Amdocal Plus?The recommended dosage is one tablet of Amdocal Plus® 50 (Amlodipine 5mg and Atenolol 50mg) or Amdocal Plus® 25 (Amlodipine 5mg and Atenolol 25 mg). Depending upon the therapeutic response, titration of the dosage is recommended. In elderly patients, it is advisable to initiate the therapy with 1/2 tablet of fixed dose combination of Amlodipine & Atenolol i.e. 2.5 mg Amlodipine & 25 mg Atenolol.If you take more Amdocal Plus than you shouldIn humans, experience with intentional overdosage of Amlodipine is limited. If massive overdosage occurs, active cardiac and respiratory monitoring should be instituted. Frequent blood pressure measurements are essential.If you forget to take Amdocal PlusIf you forget to take a dose, take it as soon as you remember it. However, if it is nearly time for the next dose, skip the missed dose. Do not take a double dose to make up for a forgotten doseIf you stop taking Amdocal PlusDo not stop taking this medicine without talking to your doctor. You should not stop taking Amdocal Plus just because you feel better. This is because the problem may come back or get worse again.If you have any further questions on the use of this product, ask your doctor or pharmacist.4. Possible side effectsLike all medicines, Amdocal Plus can cause side effects, although not everybody gets them.Amlodipine: Peripheral edema may occasionally be present but is fully reversible. As with other calcium channel blockers peripheral edema and skin erythema occur in a proportion of patients and facial flushing occurs in 2-5% of patients. Complaints of fatigue were also reported more frequently than in placebo-treated patients. There is evidence that these effects are more common in patients treated with doses greater than 10 mg daily.Atenolol: Pronounced fatigue and cold extremities have been observed in 10 to 20% of the treated subjects. Complaints about bradycardia, dizziness and gastrointestinal symptoms are less frequent. Despite its relative selectivity, Atenolol can cause bronchospasms in asthma patients.Tell your doctor if any of the side effects gets serious..
Tk.8.50/=
Amdova
1. What Amdova is and what it is used for? Amdova® is a combination product containing Amlodipine Besilate BP equivalent to 5 mg Amlodipine, a calcium channel blocker and Atorvastatin calcium INN equivalent to 10 mg Atorvastatin, a statin (HMG-CoA reductase inhibitor). Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Atorvastatin calcium is a synthetic lipid-lowering agent. It is an inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA). This enzyme catalyzes the conversion of HMG-CoA to mevatonate, an early and rate limiting step in the synthesis of cholesterol.Patients in whom treatment with Amlodipine and Atorvastatin is appropriate at the dose presented, which include hypertension, chronic stable angina, an adjunct to diet for hypercholesterolemia and in hypertensive patient with multiple risk factors for CHD to reduce the risk of non fatal MI and non fatal stroke. 2. Before you take Amdova Do not take this medicine and tell your doctor if: Amlodipine is contraindicated in patients with known hypersensitivity to Amlodipine. Atorvastatin is contraindicated in hypersensitivity to any component of this medication. Active liver disease or unexplained persistent elevations of serum transaminases exceeding three times the upper limit of normal. Do not take this medicine if the above applies to you. If you are not sure, talk to your doctor before taking Amdova. Take special care with AmdovaSince the vasodilatation induced by Amlodipine is gradual in onset, acute hypotension has rarely been reported after oral administration of Amlodipine. Nonetheless, caution should be exercised when administering Amlodipine as with any other peripheral vasodilator particularly in patients with severe aortic stenosis. Use in Patients with Congestive Heart Failure: Although hemodynamic studies and a controlled trial in Class-II-III heart failure patients have shown that amlodipine did not lead to clinical deterioration as measured by exercise tolerance, left ventricular ejection fraction, and clinical symptoms. In general, all calcium channel blockers should be used with caution in patients with heart failure. Rhabdomyolysis with acute renal failure secondary to myoglobinuria has been reported with other drugs in the statin class. Atorvastatin may cause an elevation in serum creatine phosphokinase levels. This should be considered in the differential diagnosis of chest pain in patients on therapy with Atorvastatin. Uncomplicated myalgia has been reported in Atorvastatin-treated patients. Atorvastatin therapy should be discontinued if markedly elevated CPK levels occur or myopathy is diagnosed or suspected. Taking other medicines Caution should be exercised when administering Amlodipine as with any other peripheral vasodilator particularly in patients with severe aortic stenosis. Pregnancy and breast-feeding Safety in pregnancy has not been established. 3. How to take Amdova? Amlodipine: The usual initial antihypertensive oral dose is 5 mg once daily with a maximum dose of 10 mg once daily. Elderly individuals or patients with hepatic insufficiency may be started on 2.5 mg once daily dose and this dose may be used when adding Amlodipine to other antihypertensive therapy. Dosage should be adjusted according to each patient's need. The recommended dose for chronic stable or vasospastic angina is 5-10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency. Atorvastatin: Adults: The patient should be placed on a standard cholesterol-lowering diet before receiving Atorvastatin and should continue on this diet during treatment with Atorvastatin Hypercholesterolemia (Heterozygous Familial and Nonfamilial) and Mixed Dyslipidemia (Fredrickson Types IIa and IIb): The recommended starting dose of Atorvastatin is 10 mg daily. The dosage range is 10 to 80 mg once daily. Atorvastatin can be administered as a single dose at any time of the day with or without food. Homozygous Familial Hypercholesterolemia: The dosage of Atorvastatin in patients with homozygous FH is 10 to 80 mg daily. Patients with renal insufficiency: Renal disease has no influence on the plasma concentrations or lipid effects of Atorvastatin; thus no adjustment of dose is required. Hemodialysis is not expected to significantly enhance the clearance of Atorvastatin since the drug is extensively bound to plasma proteins. Patients with hepatic dysfunction: In patients with moderate to severe hepatic dysfunction, the therapeutic response to Atorvastatin is unaffected but exposure to the drug is greatly increased. If you take more Amdova than you should In humans, experience with intentional overdosage of Amlodipine & Atorvastatin is limited. If massive overdosage occurs, act..
Tk.11.00/=
Amlopin 5mg Tab
Amlopin 5mg TabDESCRIPTIONAMLOPIN (Amlodipine) is 3rd generation a dihydropyridine calciumchannel blocker, with a long duration of action, used for the treatment of hypertension and angina pectoris. AMLOPIN (Amlodipine) influences the myocardial cells, the cells within the specialised conducting system of the heart, and the cells of vascular smooth muscle. Administration of AMLOPIN (Amlodipine) results primarily in vasodilation, with reduced peripheral resistance, blood pressure and afterload, increased coronary blood flow and a reflex increase in coronary heart rate. This in turn results in an increase in myocardial oxygen supply and cardiac output.COMPOSITIONTablet 5 : Each tablet contains Amlodipine INN (as Besylate) 5 mg.Tablet 10 : Each tablet contains Amlodipine INN (as Besylate) 10 mg.INDICATIONSHypertension : AMLOPIN is effective as monotherapy in the treatment of hypertension. It may be used in combination with other antihypertensive agents.Angina pectoris : AMLOPIN is indicated for the treatment of chronic stable angina pectoris and is effective as monotherapy. It may be used in combination with other antianginal agents. Vasospastic angina : AMLOPIN is indicated for the treatment of confirmed or suspected vasospastic angina. It may be used as monotherapy or in combination with other antianginal drugs.DOSAGE AND ADMINISTRATIONHypertension : Usual dose is 5 mg once daily. Maximum dose is 10 mg once daily.Elderly individuals and patients with hepatic insufficiency may be started on 2.5 mg once daily; this dose may also be used when adding AMLOPIN to other antihypertensive therapy. Angina (Chronic stable or vasospastic) : 5-10 mg, using the lower dose for elderly and in patients with hepatic insufficiency. Most patients require 10 mg.May be taken without regard to meals.OR AS DIRECTED BY THE PHYSICIAN.SIDE EFFECTSThe commonest side effects of Amlodipine are associated with the vasodilatory action, such as dizziness, flushing, headache, hypotension and peripheral oedema. Gastrointestinal disturbances, increased micturition frequency, lethargy, eye pain and mental depression may also occur. A paradoxical increase in ischaemic chest pain may occur at the start of the treatment and in a few patients excessive fall in blood pressure has led to cerebral or myocardial ischaemia or transient blindness. Rashes, fever and abnormalities in liver function due to hypersensitivity reaction of Amlodipine may occur.PRECAUTIONSPrecaution should be taken in patients with hepatic impairment, during pregnancy and breast feeding.DRUG INTERACTIONSPotentially hazardous interactions : Little or no data is available in patients with markedly impaired cardiac left ventricular function; however, as with other calcium antagonist drugs, the combination of Amlodipine and b-blockers should be avoided in such patients. Other significant interactions : Digoxin : Absence of any interaction between Amlodipine and Digoxin in healthy volunteers has been documented in a controlled clinical study. Cimetidine : No interaction between Amlodipine and Cimetidine in healthy volunteers has been noted. Warfarin : Amlodipine did not significantly alter the effect of warfarin on prothrombin time. Food : Food does not alter the rate or extent of absorption of Amlodipine.CONTRAINDICATIONSHypersensitivity to dihydropyridine derivatives. Pregnant woman.SUPPLYTablet 5 : Each box contains 3 X 10 tablets in blisters.Tablet 10 : Each box contains 3 X 10 tablets in blisters...
Tk.5.01/=
Amlosartan 10/160 Tab
Indications Amlodipine and Valsartan combination is indicated for the treatment of hypertension. This fixed combination drug is not indicated for the initial therapy of hypertension Therapeutic Class Combined antihypertensive preparations Pharmacology Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Valsartan blocks the vasoconstrictor and aldosterone-secreting effects of Angiotensin II by selectively blocking the binding of Angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for Angiotensin II synthesis. Amlodipine and Valsartan have been shown to be effective in lowering blood pressure. Both Amlodipine and Valsartan lower blood pressure by reducing peripheral resistance, but calcium influx blockade and reduction of Angiotensin II vasoconstriction are complementary mechanisms. Dosage & Administration Amlodipine is an effective treatment of hypertension in once daily doses of 2.5 mg-10 mg while Valsartan is effective in doses of 80 mg-320 mg. In clinical trials with Amlodipine and Valsartan combination using Amlodipine doses of 5 mg-10 mg and Valsartan doses of 160 mg-320 mg, the antihypertensive effects increased with increasing doses. Interaction No drug interaction studies have been conducted with Amlodipine and Valsartan combination and other drugs, although studies have been conducted with the individual Amlodipine and Valsartan components Contraindications Amlodipine and Valsartan combination is contraindicated in patients who are hypersensitive to any compounds of this product. Side Effects The most common side effects include peripheral edema, vertigo, nasopharyngitis, upper respiratory tract infection and dizziness. Pregnancy & Lactation Pregnancy: Amlodipine and Valsartan combination should not be used in 2nd and 3rd trimester because it can cause fetal death .Nursing Mothers: It is not known whether Valsartan and Amlodipine are excreted in human milk. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Precautions Amlosartan should be used with caution because there is a risk for fetal or neonatal morbidity, hypotension, myocardial infarction or increased angina.Dose should be titrated slowly in patients with impaired hepatic or severely impaired renal function. In general, calcium channel blockers should be used with caution in patients with heart failure. Overdose Effects Limited data of human overdosage have been reported. Use in Special Population Pediatric use: The safety and effectiveness has not been established in pediatric patients.Geriatric use: No differences in overall incidence of adverse events were observed in elderly.Renal impairment: No initial dosage adjustment is required for patients with mild or moderate renal impairment. Titrate slowly in patients with severe renal impairment. Hepatic impairment: No initial dosage adjustment is required for patients with mild or moderate liver insufficiency. Titrate slowly in patients with hepatic impairment. Storage Conditions Store in a cool dry place protected from light. Keep out of reach of children. ..
Tk.9.00/=
Amlosartan 5/160 Tab
Indications Amlodipine and Valsartan combination is indicated for the treatment of hypertension. This fixed combination drug is not indicated for the initial therapy of hypertension Therapeutic Class Combined antihypertensive preparations Pharmacology Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Valsartan blocks the vasoconstrictor and aldosterone-secreting effects of Angiotensin II by selectively blocking the binding of Angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for Angiotensin II synthesis. Amlodipine and Valsartan have been shown to be effective in lowering blood pressure. Both Amlodipine and Valsartan lower blood pressure by reducing peripheral resistance, but calcium influx blockade and reduction of Angiotensin II vasoconstriction are complementary mechanisms. Dosage & Administration Amlodipine is an effective treatment of hypertension in once daily doses of 2.5 mg-10 mg while Valsartan is effective in doses of 80 mg-320 mg. In clinical trials with Amlodipine and Valsartan combination using Amlodipine doses of 5 mg-10 mg and Valsartan doses of 160 mg-320 mg, the antihypertensive effects increased with increasing doses. Interaction No drug interaction studies have been conducted with Amlodipine and Valsartan combination and other drugs, although studies have been conducted with the individual Amlodipine and Valsartan components Contraindications Amlodipine and Valsartan combination is contraindicated in patients who are hypersensitive to any compounds of this product. Side Effects The most common side effects include peripheral edema, vertigo, nasopharyngitis, upper respiratory tract infection and dizziness. Pregnancy & Lactation Pregnancy: Amlodipine and Valsartan combination should not be used in 2nd and 3rd trimester because it can cause fetal death .Nursing Mothers: It is not known whether Valsartan and Amlodipine are excreted in human milk. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Precautions Amlosartan should be used with caution because there is a risk for fetal or neonatal morbidity, hypotension, myocardial infarction or increased angina.Dose should be titrated slowly in patients with impaired hepatic or severely impaired renal function. In general, calcium channel blockers should be used with caution in patients with heart failure. Overdose Effects Limited data of human overdosage have been reported. Use in Special Population Pediatric use: The safety and effectiveness has not been established in pediatric patients.Geriatric use: No differences in overall incidence of adverse events were observed in elderly.Renal impairment: No initial dosage adjustment is required for patients with mild or moderate renal impairment. Titrate slowly in patients with severe renal impairment. Hepatic impairment: No initial dosage adjustment is required for patients with mild or moderate liver insufficiency. Titrate slowly in patients with hepatic impairment. Storage Conditions Store in a cool dry place protected from light. Keep out of reach of children. ..
Tk.8.00/=
Amlosartan 5/80 Tab
Amlosartan 5/80 TabPresentationAmlosartan 5/80: Each tablet contains Amlodipine Besilate BP equivalent to Amlodipine 5 mg & Valsartan USP 80 mg.DescriptionAmlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Amlodipine has a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.Valsartan is an oral medication that belongs to a class of drugs called angiotensin receptor blockers (ARBs). It is orally active and specific angiotensin II antagonist acting on the AT1 subtype. Angiotensin's attachment to the receptors causes the blood vessels to narrow (vasoconstrict) which leads to an increase in blood pressure (hypertension). Valsartan blocks the angiotensin II receptor. By blocking the action of angiotensin, Valsartan dilates blood vessels and reduces blood pressure without affecting pulse rate. Valsartan has much greater affinity (about 20,000-fold) for the AT1 receptor than for the AT2 receptor. It does not bind or block other hormone receptors or ion channels known to be important in cardiovascular regulation.IndicationsAmlosartan is indicated for the treatment of hypertension. This combination drug is not indicated for the initial therapy of hypertension.Dosage & AdministrationAmlodipine is an effective treatment of hypertension in once daily doses of 2.5 mg to 10 mg while Valsartan is effective in doses of 80 mg to 320 mg. The majority of the antihypertensive effect is attained within 2 weeks after initiation of therapy or a change in dose. The dosage can be increased after 1 to 2 weeks of therapy to a maximum of one 10/320 mg tablet once daily as needed to control blood pressure.Amlosartan may be administered with or without food. Amlosartan may be administered with other antihypertensive agents. A patient whose blood pressure is not adequately controlled with Amlodipine alone or with Valsartan alone may be switched to their combination therapy.Elderly patients: Because of decreased clearance of Amlodipine, therapy should usually be initiated at 2.5 mg.Renal impairment: No initial dosage adjustment is required for patients with mild or moderate renal impairment. Titrate slowly in patients with severe renal impairment.Hepatic impairment: No initial dosage adjustment is required for patients with mild or moderate liver insufficiency. Titrate slowly in patients with hepatic impairment.Side EffectsThe most common side effects include peripheral edema, vertigo, nasopharyngitis, upper respiratory tract infection and dizziness.PrecautionsAmlosartan should be used with caution because there is a risk for-fetal or neonatal morbidityhypotensionmyocardial infarction or increased anginaDose should be titrated slowly in patients with impaired hepatic or severely impaired renal function. In general, calcium channel blockers should be used with caution in patients with heart failure.Use in Pregnancy & LactationPregnancy: Amlodipine and Valsartan combination should not be used in 2nd and 3rd trimester because it can cause fetal death .Nursing Mothers: It is not known whether Valsartan and Amlodipine are excreted in human milk. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.Over DoseLimited data of human overdosage have been reported.Commercial PackAmlosartan 5/80: Each box contains 3 alu-alu blister strips of 10 tablets...
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Amloten 5/ 25 mg Tablet
Amloten 5/ 25 mg TabletDescriptionAMLOTEN is a fixed-dose combination of amlodipine and atenolol. Amlodipine is a calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle; it has a greater effect on vascular smooth muscle cells than on cardiac muscle cells. It is a peripheral vasodilator, acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Atenolol is a selective β1 blocker. Atenolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS. Atenolol also causes a reduction in myocardial oxygen demand by virtue of its negative inotropic and negative chronotropic effects.CompositionAMLOTEN 25 : Each tablet contains Amlodipine Besylate BP equivalent to Amlodipine 5 mg and Atenolol BP 25 mg. AMLOTEN 50 : Each tablet contains Amlodipine Besylate BP equivalent to Amlodipine 5 mg and Atenolol BP 50 mg.IndicationsThe combination is indicated for the treatment of hypertension and chronic stable angina.Dosage and AdministrationThe recommended dosage is one tablet of AMLOTEN 25 or AMLOTEN 50 daily. If necessary, the dosage may be increased to two tablets daily. The dosage, however, should be individualized.OR AS DIRECTED BY THE PHYSICIAN.Side effectsThe combination of amlodipine and atenolol is well tolerated. Side effects include headache, palpitations, flushing, edema, depression, dizziness, dyspepsia, dyspnoea, muscle cramps, fatigue, cold extremities and bradycardia.ContraindicationsIt is contraindicated in hypersensitivity to any components of the product, sinus bradycardia, second and higher degrees of heart block, cardiogenic shock, hypotension, congestive heart failure, poor left ventricular function. Precautions Bronchospasm: The combination should be used with caution in patients with airway obstruction.Renal Impairment: The combination can be used in patients with renal impairment. However, caution may be necessary if the creatinine clearance is less than 30 ml/min. Hepatic Impairment: Caution may be necessary in the use of the combination in patients with severe liver damage because of prolongation of the elimination half- life of amlodipine.Drug Withdrawal: Since coronary heart disease may exist without being recognized, patients should be warned against stopping the drug suddenly. Any discontinuation should be gradual and under observation. Hypotension : Excessive fall of blood pressure can occur in some patients especially the elderly.Use in Pregnancy & LactationIn Pregnancy: The combination should be used during pregnancy only if the expected benefit outweighs the potential fetal risk. In Lactation: The combination should not be used by nursing mothers. If its use is considered necessary, breast feeding should be stopped.Drug InteractionsDisopyramide: Atenolol reduces the clearance of disopyramide by 20%. Additive negative inotropic effects on the heart may be produced. Ampicillin: Ampicillin at doses of 1 g and above may reduce atenolol levels. Oral antidiabetic and insulin: Beta-blockers may decrease tissue sensitivity to insulin and inhibit insulin secretion e.g. in response to oral antidiabetics. Atenolol has less potential for these actions.OverdosageThough not documented, hypotension and less frequently congestive cardiac failure may occur in cases of overdosage. Unabsorbed drugs may be removed by gastric lavage or administration of activated charcoal. Symptomatic treatment is suggested.SupplyAMLOTEN 25: Each box contains 3X10 tablets in Alu-Alu blister.AMLOTEN 50: Each box contains 3X10 tablets in Alu-Alu blister. ..
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Amloten 5/50 mg Tablet
Amloten 5/50 mg TabletDescriptionAMLOTEN is a fixed-dose combination of amlodipine and atenolol. Amlodipine is a calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle; it has a greater effect on vascular smooth muscle cells than on cardiac muscle cells. It is a peripheral vasodilator, acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Atenolol is a selective β1 blocker. Atenolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS. Atenolol also causes a reduction in myocardial oxygen demand by virtue of its negative inotropic and negative chronotropic effects.CompositionAMLOTEN 25 : Each tablet contains Amlodipine Besylate BP equivalent to Amlodipine 5 mg and Atenolol BP 25 mg. AMLOTEN 50 : Each tablet contains Amlodipine Besylate BP equivalent to Amlodipine 5 mg and Atenolol BP 50 mg.IndicationsThe combination is indicated for the treatment of hypertension and chronic stable angina.Dosage and AdministrationThe recommended dosage is one tablet of AMLOTEN 25 or AMLOTEN 50 daily. If necessary, the dosage may be increased to two tablets daily. The dosage, however, should be individualized.OR AS DIRECTED BY THE PHYSICIAN.Side effectsThe combination of amlodipine and atenolol is well tolerated. Side effects include headache, palpitations, flushing, edema, depression, dizziness, dyspepsia, dyspnoea, muscle cramps, fatigue, cold extremities and bradycardia.ContraindicationsIt is contraindicated in hypersensitivity to any components of the product, sinus bradycardia, second and higher degrees of heart block, cardiogenic shock, hypotension, congestive heart failure, poor left ventricular function. Precautions Bronchospasm: The combination should be used with caution in patients with airway obstruction.Renal Impairment: The combination can be used in patients with renal impairment. However, caution may be necessary if the creatinine clearance is less than 30 ml/min. Hepatic Impairment: Caution may be necessary in the use of the combination in patients with severe liver damage because of prolongation of the elimination half- life of amlodipine.Drug Withdrawal: Since coronary heart disease may exist without being recognized, patients should be warned against stopping the drug suddenly. Any discontinuation should be gradual and under observation. Hypotension : Excessive fall of blood pressure can occur in some patients especially the elderly.Use in Pregnancy & LactationIn Pregnancy: The combination should be used during pregnancy only if the expected benefit outweighs the potential fetal risk. In Lactation: The combination should not be used by nursing mothers. If its use is considered necessary, breast feeding should be stopped.Drug InteractionsDisopyramide: Atenolol reduces the clearance of disopyramide by 20%. Additive negative inotropic effects on the heart may be produced. Ampicillin: Ampicillin at doses of 1 g and above may reduce atenolol levels. Oral antidiabetic and insulin: Beta-blockers may decrease tissue sensitivity to insulin and inhibit insulin secretion e.g. in response to oral antidiabetics. Atenolol has less potential for these actions.OverdosageThough not documented, hypotension and less frequently congestive cardiac failure may occur in cases of overdosage. Unabsorbed drugs may be removed by gastric lavage or administration of activated charcoal. Symptomatic treatment is suggested.SupplyAMLOTEN 25: Each box contains 3X10 tablets in Alu-Alu blister.AMLOTEN 50: Each box contains 3X10 tablets in Alu-Alu blister. ..
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Amlotab 10 Tablet
DescriptionAmlodipine is a Dihydropyridine Calcium antagonist that inhibits the transmembrane influx of Calcium ions into cardiac and vascular smooth muscle. It has greater affinity towards vascular smooth muscle than on cardiac muscle. Amlodipine is peripheral vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and thereby reduces blood pressure. Amlodipine reduces tone, decreases coronary vasoreactivity and lowers cardiac oxygen demand by reducing after load.IndicationsPatients with mild to moderate hypertension (alone or in combination with other antihypertensives).The treatment of chronic stable and vasospastic angina.Raynaud\'s disease.Dosage & AdministrationFor treatment of both hypertension and angina pectoris, the usual initial dose is 5 mg once daily. If the desired therapeutic effect cannot be achieved within 2-4 weeks, the dose may be increased to a maximum dose of 10 mg once daily. Amlodipine 10 mg once daily provides symptomatic improvement in patients with Raynaud's disease.Use in children: Use of Amlodipine in children (under 12 years of age) is not recommended.Side EffectsAmlodipine is generally well tolerated. The most commonly observed side effects are headache, peripheral oedema, palpitations, flushing, dizziness, nausea, abdominal pain.PrecautionsUse in renal failureAlthough Amlodipine is excreted primarily via kidney, mild renal impairment does not appear to have an effect on the plasma concentrations. Severe renal impairment may however require a dosage reduction. Amlodipine is not dialyzable.Use in patients with impaired hepatic functionAmlodipine half-life is prolonged in patient with impaired hepatic function. Amlodipine should therefore be administered at lower (5mg) initial dose in these patients.Use in heart failureAn increased number of pulmonary oedema has been reported.Use in Pregnancy & LactationPregnancy: Safety in pregnancy has not been established.Lactation: It is not known whether Amlodipine is excreted in breast milk. It is advised to stop breastfeeding during treatment with Amlodipine.Over DoseThere is no well documented experience with Amlodipine overdosage. In case of clinically significant hypotension due to Amlodipine over dosage, calls for active cardiovascular support including monitoring of cardiac and respiratory function, elevation of extremities and attention to circulating fluid volume and urine output. Since Amlodipine is highly protein-bound, dialysis is unlikely to be of benefit...
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Telmidip 80/5 Tablet
DescriptionTelmidip is a fixed dose combination of Telmisartan and Amlodipine. Telmisartan, a non-peptide angiotensin receptor blocker (ARB), is specific angiotensin II antagonist acting on the AT1 subtype. Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium, which leads to an increase in blood pressure (hypertension). Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Therefore, Telmisartan dilates blood vessels and reduces blood pressure without affecting pulse rate. Telmisartan has much greater affinity (>3,000 fold) for the AT1 receptor than for the AT2 receptor. It does not bind or block other hormone receptors or ion channels known to be important in cardiovascular regulation. Amlodipine, a dihydropyridine calcium-channel blocker (CCB), inhibits the transmembrane influx of calcium ion into vascular smooth muscle and cardiac muscle. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.IndicationsTelmidip is indicated for the treatment of hypertension, alone or with other antihypertensive agents. It may also be used as initial therapy in patients who are likely to need multiple drugs to achieve their blood pressure goals.Dosage & AdministrationInitial Therapy: Patient may be initiated on Telmidip tablets if it is unlikely that control of blood pressure would be achieved with a single agent. The usual starting dose is 40/5 mg once daily. Patients requiring larger blood pressure reductions may be started with 80/5 mg once daily. Initial therapy with Telmidip is not recommended in patients ≥75 years old or with hepatic impairment.Add-on Therapy: Patients not adequately controlled with amlodipine (or another dihydropyridine calcium channelblocker) alone or with telmisartan (or another angiotensin receptor blocker) alone. Patients treated with 10 mg amlodipine who experience adverse reactions such as edema, may be switched to Telmidip 40/5 mg tablets once daily, reducing the dose of amlodipine without reducing the overall expected antihypertensive response.Replacement Therapy: Patients receiving amlodipine and telmisartan from separate tablets may instead receive Telmidip tablets containing the same component doses once daily. Dosage must be individualized and may be increased after at least 2 weeks. The maximum recommended dose of Telmidip tablet is 80/10 mg once daily.Side EffectsDizziness, peripheral edema, migraine, headache, paraesthesia, vertigo, bradycardia, palpitations, hypotension, cough, abdominal pain, diarrhea, nausea, pruritus, myalgia, spasm, erectile dysfunction, chest pain, fatigue, edema etc.Precautions• Avoid fetal or neonatal exposure• Hypotension: Correct any volume or salt depletion before initiating therapy. Observe for signs and symptoms of hypotension.• Titrate slowly in patients with hepatic or severe renal impairment• Heart failure: Monitor for worsening• Avoid concomitant use of an ACE inhibitor and angiotensin receptor blocker• Myocardial infarction: Uncommonly, initiating a CCB in patients with severe obstructive coronary artery disease may precipitate myocardial infarction or increased anginaUse in Pregnancy & LactationPregnancy: Pregnancy Categories C (first trimester) and D (second and third trimesters).Lactation: It is not known whether telmisartan and amlodipine is excreted in human milk. Because of the potential for adverse effects on the nursing infant, discontinue nursing or discontinue the drug after taking into account the importance of the drug to the mother.Drug InteractionCo-administration of telmisartan did not result in a clinically significant interaction with acetaminophen, amlodipine, glyburide, simvastatin, hydrochlorothiazide, warfarin, or ibuprofen. Telmisartan is not metabolized by the cytochrome P450 system and had no effects in vitro on cytochrome P450 enzymes, except for some inhibition of CYP2C19. Telmisartan is not expected to interact with drugs that inhibit or are metabolized by cytochrome P450 enzymes, except for possible inhibition of the metabolism of drugs metabolized by CYP2C19. In clinical trials, amlodipine has been safely administered with thiazide diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycemic drugs. The following have no clinically relevant effects on the pharmacokinetics of amlodipine: cimetidine, grapefruit juice, sildenafil. Amlodipine has no clinically relevant effects on the pharmacoki..
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