Eyemox Eye Drops 5 ml drop

Eyemox Eye Drops 5 ml drop

DESCRIPTION

Eyemox (Moxifloxacin) is an 8-methoxy fluoroquinolone with a diazabicyclononyl ring at the C7 position. The bacterial action of moxifloxacin results from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV.

COMPOSITION

Each ml contains Moxifloxacin HCl BP equivalent to 5 mg Moxifloxacin.

INDICATIONS

Eyemox is indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms:

DOSAGE AND ADMINISTRATION

Instill one drop in the affected eye 3 times a day for 7(seven) days.

OR AS DIRECTED BY THE PHYSICIAN.

SIDE EFFECTS

The most frequently reported ocular adverse events were decreased visual acuity, dry eye, keratitis, ocular discomfort, ocular hyperemia, ocular pain, ocular pruritus, subconjunctival hemorrhage, and tearing.

These events occurred in approximately 1-6 % of patients.

Nonocular adverse events reported at a rate of 1-4 % were fever, increased cough, infection, otitis media, pharyngitis, rash and rhinitis.

CONTRAINDICATIONS

Moxifloxacin Eye Drops is contraindicated in patients with a history of hypersensitivity to Moxifloxacin, to other quinolones, or to any of the components in this medication.

PRECAUTIONS

As with other anti-infectives, prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patients should be examined with the aid of magnification, such as slit-lamp biomicroscopy, and where appropriate, fluorescein staining.

Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis.

USE IN PREGNANCY

Since there are no adequate and well -controlled studies in pregnant women, Moxifloxacin Eye Drops should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

USE IN LACTATION

Moxifloxacin has not been measured in human milk, although it can be presumed to be excreted in human milk. Caution should be exercised when Moxifloxacin Eye Drops is administered to a nursing mother.

DRUG INTERACTIONS

Drug-drug interaction studies have not been conducted with Moxifloxacin. In vitro studies indicate that Moxifloxacin does not inhibit

CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP1A2 indicating that

Moxifloxacin is unlikely to alter the pharmacokinetics of drugs metabolized by these cytochrome P450 isozymes.

SUPPLY

Eyemox Eye Drops : 5 ml eye drops is supplied in 5 ml plastic droper bottle.