ITRA 100mg/cap

Overview

Itra (Itraconazole) 100 mg Capsule is a broad-spectrum triazole antifungal agent manufactured by Square Pharmaceuticals PLC. It inhibits Cytochrome P-450 dependent enzymes, thereby impairing the biosynthesis of ergosterol — a vital component of the fungal cell membrane — which leads to inhibition of fungal growth and abnormal cell wall formation. Itra is indicated for a wide range of fungal infections including oropharyngeal and vulvovaginal candidiasis, pityriasis versicolor, tinea infections (tinea pedis, tinea cruris, tinea corporis, tinea manuum), onychomycosis, histoplasmosis, systemic candidiasis, aspergillosis, and cryptococcosis.

Dosage and Administration

Vulvovaginal candidiasis: 200 mg twice daily for 1 day. Pityriasis versicolor: 200 mg once daily for 7 days. Tinea corporis/cruris: 100 mg once daily for 15 days or 200 mg once daily for 7 days. Tinea pedis/manuum: 100 mg once daily for 30 days. Oropharyngeal candidiasis: 100 mg once daily for 15 days (increase to 200 mg in AIDS/neutropenic patients). Onychomycosis: 200 mg daily for 3 months or pulse therapy (200 mg twice daily for 7 days, repeated after 21 days). Aspergillosis: 200 mg once daily for 2–5 months. Systemic candidiasis: 100–200 mg daily for 3 weeks to 7 months. Cryptococcal meningitis: 200 mg twice daily for 2–6 months. Take after a full meal to optimize absorption. Follow the prescribing physician's specific instructions for duration and dosage adjustment.

Interaction

Terfenadine, astemizole, cisapride, HMG-CoA reductase inhibitors (e.g. simvastatin), oral midazolam, and triazolam must not be used concurrently with Itra. Significant interactions have been observed with rifampin, phenytoin, phenobarbital, digoxin, and calcium channel blockers. Antacids (e.g. aluminium hydroxide) should be taken at least 2 hours after Itra as they impair absorption.

Contraindications

Itra is contraindicated in patients with known hypersensitivity to itraconazole or any component of the formulation. It is not advised in patients with severe hepatic disease or in those taking rifampin concomitantly.

Side Effects

Common side effects include nausea, abdominal pain, dyspepsia, constipation, headache, dizziness, raised liver enzymes, menstrual disorders, and allergic reactions (pruritus, rash, urticaria, angioedema). Rarely, hepatitis, cholestatic jaundice, peripheral neuropathy, and Stevens-Johnson syndrome may occur. Prolonged use may cause hypokalemia, edema, and hair loss.

Pregnancy and Lactation

Itraconazole is contraindicated in pregnancy. Breastfeeding while receiving Itra is not recommended.

Precautions and Warnings

Take Itra after a full meal to maximize absorption. If gastric acid-reducing agents are co-prescribed, take them at least 2 hours after Itra. Liver function should be monitored in patients receiving continuous treatment for more than one month. Report any yellowing of eyes or skin, dark urine, or abdominal pain to the treating physician. Use reliable contraception during treatment. Do not take antacids within 2 hours of Itra.

Storage Conditions

Store below 25°C in a cool, dry place protected from light. Keep out of the reach of children.

Frequently Asked Questions

Q: Should Itra 100 mg capsule be taken with or without food?
A: Itra should be taken after a full meal to maximize its absorption. Avoid taking antacids within 2 hours of the dose, as they reduce bioavailability.

Q: How long does Itra treatment usually last?
A: Duration varies by indication — from as short as 1 day for vulvovaginal candidiasis to several months for systemic fungal infections or onychomycosis. Always complete the full course as directed by your physician.