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- Product ID: Cephradine
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Abac-500 500mg Capsule
Generic Name: Cephradine BP 500mg
Manufacturer: Beximco Pharmaceuticals Ltd.
Drug Class: First-Generation Cephalosporin Antibiotic
Dosage Form: Hard Gelatin Capsule
Prescription Status: Prescription Only (Rx)
Mechanism of Action
Cephradine is a bactericidal first-generation cephalosporin antibiotic. It exerts its effect by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking and causing osmotic lysis of susceptible bacteria. It is well absorbed orally and achieves good tissue penetration.
Spectrum of Activity
| Sensitivity | Organisms |
|---|---|
| Susceptible | Staphylococcus aureus (MSSA), Streptococcus pyogenes, S. pneumoniae, E. coli, Klebsiella pneumoniae, Proteus mirabilis, H. influenzae |
| Resistant | MRSA, Pseudomonas aeruginosa, Enterococcus spp., ESBL-producing organisms, Bacteroides fragilis |
Indications
- Upper and lower respiratory tract infections (pharyngitis, tonsillitis, bronchitis, community-acquired pneumonia)
- Urinary tract infections — uncomplicated cystitis
- Skin and soft tissue infections (cellulitis, impetigo, wound infections, folliculitis)
- Bone and joint infections (step-down oral therapy)
- Prophylaxis in minor surgical procedures
Dosage and Administration
| Indication | Adult Dose | Frequency | Duration |
|---|---|---|---|
| Mild–moderate infections | 250–500 mg | Every 6 hours | 7–10 days |
| Severe infections | 500 mg–1g | Every 6 hours | 10–14 days |
| UTI (uncomplicated) | 500 mg | Every 12 hours | 7 days |
| Streptococcal pharyngitis | 500 mg | Every 12 hours | 10 days minimum |
May be taken with or without food. Complete the full course. Maximum adult dose: 4g/day.
Important Notice for Diabetic Patients
- Diabetic foot infections: Cephradine covers gram-positive organisms (MSSA, Streptococcus) but NOT MRSA or gram-negative bacilli — culture results essential; empiric use alone is insufficient for moderate-to-severe diabetic foot infections
- Diabetic UTIs: Appropriate for uncomplicated lower UTI; however, diabetic patients with complicated or recurrent UTIs require urine C&S — Klebsiella and ESBL-producing E. coli are common and may be resistant
- Renal dose adjustment (diabetic nephropathy):
CrCl >20 ml/min: standard dose every 6 hours
CrCl 5–20 ml/min: 250mg every 6–12 hours
CrCl <5 ml/min: 250mg every 12–24 hours; use with caution - False-positive urine glucose tests: Cephradine may cause false-positive results with copper reduction methods (Clinitest, Benedict's solution). Use glucose oxidase dipstick tests only
- Infection-related hyperglycaemia: Active bacterial infection may worsen glycaemic control — intensify blood glucose monitoring during antibiotic treatment
Contraindications
- Known hypersensitivity to cephradine or any cephalosporin
- Immediate-type hypersensitivity reaction to penicillins (cross-reactivity possible)
- Severe renal impairment without dose adjustment
Side Effects
| System | Side Effects |
|---|---|
| Gastrointestinal | Nausea, vomiting, diarrhoea, abdominal cramps, C. difficile colitis (rare) |
| Hypersensitivity | Skin rash, urticaria, pruritus, anaphylaxis (rare) |
| Haematological | Eosinophilia, neutropenia, positive Coombs test |
| Hepatic/Renal | Transient elevation of LFTs; increased creatinine at high doses |
Drug Interactions
- Probenecid: Reduces renal tubular secretion of cephradine, increasing plasma levels
- Aminoglycosides: Additive nephrotoxicity risk; monitor renal function
- Warfarin: Cephalosporins may potentiate anticoagulant effect — INR monitoring advised
- Metformin: No direct interaction; if renal function deteriorates, metformin dose review may be required
Storage
Store below 30°C in a cool, dry place away from moisture and direct sunlight. Keep out of reach of children.
Medical Disclaimer
The information provided here is for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or pharmacist before starting, stopping, or altering any medication. Antibiotic therapy should be guided by culture and sensitivity results where possible. DiabetesStore.com.bd does not endorse self-medication. Seek immediate medical attention in case of any adverse reaction.
