Azin 50 ml. susp

Azin 50ml Suspension — Azithromycin 200mg/5ml by Acme Laboratories for Larger Paediatric and Adult Courses

About Azin 50ml Suspension

Azin 50ml Suspension contains azithromycin 200 mg per 5 mL in a 50 mL bottle, providing 2000 mg total azithromycin per bottle — manufactured by Acme Laboratories Limited, Bangladesh. The 50 mL bottle is the largest single-bottle volume in the Azin suspension range and serves two important clinical populations: older and heavier children (25–40 kg) who require higher volume doses that exceed the capacity of the 30 mL bottle for 5-day courses; and adult patients who are unable to swallow tablets and need a liquid azithromycin formulation for any reason (dysphagia, nasogastric tube feeding, severe nausea). The 2000mg total content also makes it suitable for adult 3-day respiratory courses (3 × 12.5mL = 37.5mL, within the 50mL volume).

Pertussis (Whooping Cough): Treatment and Post-Exposure Prophylaxis

Bordetella pertussis, the causative organism of whooping cough (pertussis), produces a highly distinctive whooping cough illness characterised by paroxysmal coughing spells followed by an inspiratory whoop, post-tussive vomiting, and prolonged cough lasting weeks to months. Azithromycin is the first-choice antibiotic for pertussis treatment and post-exposure prophylaxis (PEP) in both children and adults. For pertussis treatment in children and adolescents: azithromycin 10mg/kg/day (max 500mg) for 5 days. Azin 50ml Suspension at 10mg/kg/day for 5 days: a 30kg child = 300mg/day = 7.5mL/day × 5 days = 37.5mL (fits within 50mL); a 35kg child = 350mg/day = 8.75mL/day × 5 days = 43.75mL (fits within 50mL); a 40kg child = 400mg/day = 10mL/day × 5 days = 50mL (exact match). For household PEP contacts: all household members (especially unvaccinated infants, pregnant women, and immunocompromised individuals including those with diabetes) should receive PEP within 21 days of exposure. A single prescription of Azin 50ml may cover a heavier adolescent's treatment course.

Azithromycin for Diabetic Patients with Recurrent Chest Infections

Patients with poorly controlled diabetes mellitus have impaired innate and adaptive immune function, leading to increased frequency and severity of respiratory tract infections. Some diabetic patients experience recurrent chest infections — defined as three or more lower respiratory tract infections per year — particularly those with concurrent COPD, bronchiectasis, or aspiration risk (from diabetic gastroparesis). In the management of recurrent chest infections in diabetic patients, azithromycin has two distinct therapeutic roles: acute treatment of bacterial exacerbations (standard courses of Azin 250mg/500mg tablets or suspension as appropriate); and low-dose long-term prophylaxis (250mg three times per week) which has been demonstrated to reduce exacerbation frequency in patients with COPD or bronchiectasis by approximately 50–70% (COLUMBUS and AZISTUDY trials). For diabetic patients with recurrent respiratory infections who cannot swallow tablets, Azin 50ml Suspension can be used for acute treatment courses. Long-term prophylaxis with suspension is impractical due to reconstitution stability limits — tablet form is preferred for chronic preventive therapy.

Dosing Guide for Azin 50ml Suspension

Frequently Asked Questions (FAQ)

Q1: My 35kg child was prescribed a 5-day course — is one Azin 50ml bottle enough?
Yes, comfortably. At 10mg/kg/day: 350mg/day = 8.75mL/day × 5 days = 43.75mL total. The 50mL bottle provides 6.25mL of surplus beyond what is needed, accounting for any minor measurement variation or spillage. Use a calibrated oral syringe for accurate measurement of the 8.75mL daily dose — a household teaspoon cannot accurately measure fractional millilitre volumes. Measure once per day at the same time. Do not double-dose if a dose is missed — take the missed dose as soon as you remember, unless it is almost time for the next dose.

Q2: Can the Azin 50ml suspension be used for an adult with severe nausea who cannot retain tablets?
Yes — azithromycin suspension (200mg/5mL) can be used for adults when tablets cannot be retained. Adult dose: 500mg/day = 12.5mL once daily. For a 3-day adult course: 37.5mL total — within the 50mL bottle. Administration tips for nauseous patients: take the suspension at the same time each day when nausea is at its lowest (often mid-morning for many patients); take with a small amount of food; sip slowly rather than drinking quickly; sit upright for at least 30 minutes after taking the dose. If vomiting occurs within 30 minutes of the dose, the dose has likely not been absorbed — contact your physician about whether to repeat the dose or switch to intravenous azithromycin if available.

Q3: What is the shelf life of the Azin 50ml suspension after it has been opened and reconstituted?
After adding water to reconstitute Azin 50ml Suspension, the resulting liquid suspension is stable for 10 days at room temperature. After 10 days from reconstitution, any remaining suspension must be discarded regardless of how much remains, as the drug degrades and the suspension may no longer be microbiologically safe. The unconstituted powder (before adding water) remains stable until the expiry date printed on the bottle, which is typically 2–3 years from the manufacture date. Store unconstituted powder at room temperature, away from heat and moisture. After reconstitution: keep at room temperature (not in the refrigerator unless specifically stated on the label), and shake well before each dose. Mark the reconstitution date on the bottle.

Q4: How does Azin 50ml suspension compare to a tablet for treating respiratory infections?
Clinically, Azin 50ml Suspension (200mg/5mL) and Azin tablets (250mg or 500mg) deliver equivalent drug exposure — they are bioequivalent formulations. There is no therapeutic advantage to either form in treating respiratory infections when the mg dose is the same. Practical differences: suspension is necessary for children below tablet-swallowing ability and adults with dysphagia; tablets are more convenient for patients who can swallow them (smaller daily volume, no reconstitution required, longer shelf life); tablets are preferred for chronic or long-term dosing (prophylaxis) as reconstituted suspension is only stable for 10 days. For acute respiratory infection treatment in patients who can swallow tablets, the 500mg tablet formulation with a 3-day course is generally more convenient than 12.5mL suspension × 3 days.

Medical Disclaimer: Azin 50ml Suspension by Acme Laboratories Limited must be reconstituted and dosed according to the prescriber's instructions and the patient's current weight. Discard any unused reconstituted suspension after 10 days. Do not use for viral infections such as the common cold or influenza.