Beuflox 500 Tab

What is Beuflox?

Beuflox is a brand of Ciprofloxacin, a broad-spectrum second-generation fluoroquinolone antibiotic. It is bactericidal and effective against a wide range of Gram-negative and Gram-positive aerobic bacteria.

Indications

Beuflox 500mg tablet is indicated for the treatment of: Acute uncomplicated and complicated urinary tract infections; Respiratory tract infections including acute exacerbation of chronic bronchitis and community-acquired pneumonia; Skin and soft tissue infections; Bone and joint infections; Infectious diarrhoea and typhoid fever; Uncomplicated gonorrhoea; Prophylaxis of meningococcal disease.

Pharmacology

Ciprofloxacin inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes required for DNA replication, transcription, repair and recombination. The bactericidal effect results from this dual inhibition. It has excellent oral bioavailability (~70–80%) and achieves high tissue concentrations. Half-life is approximately 4–6 hours with renal excretion being the primary route of elimination.

Dosage & Administration

Adults — oral:

• Uncomplicated urinary tract infections: 250 mg twice daily for 3 days
• Complicated urinary tract infections: 500 mg twice daily for 7–14 days
• Respiratory tract infections: 500–750 mg twice daily for 7–14 days
• Skin and soft tissue infections: 500–750 mg twice daily for 7–14 days
• Bone and joint infections: 500–750 mg twice daily for 4–6 weeks
• Infectious diarrhoea: 500 mg twice daily for 5–7 days
• Typhoid fever: 500 mg twice daily for 10 days
• Uncomplicated gonorrhoea: 500 mg as a single dose

Take with or without food. Swallow whole with plenty of fluid. Avoid antacids or mineral supplements within 2 hours of taking this medicine.

Interaction

Absorption significantly reduced by antacids, sucralfate, and products containing calcium, iron, magnesium, aluminium, or zinc. Ciprofloxacin inhibits CYP1A2 and increases plasma levels of theophylline, clozapine, and tizanidine (concurrent use with tizanidine contraindicated). May enhance the anticoagulant effect of warfarin. NSAIDs increase the risk of CNS side effects including convulsions. Dairy products and calcium-fortified juices may reduce absorption.

Contraindications

Contraindicated in patients with hypersensitivity to ciprofloxacin, other fluoroquinolones, or any excipient. Concomitant use with tizanidine is contraindicated.

Side Effects

Common: nausea, diarrhoea, vomiting, abdominal pain, headache, dizziness. Serious: QT prolongation, tendinitis and tendon rupture, peripheral neuropathy, hypersensitivity reactions, Clostridioides difficile-associated diarrhoea.

Pregnancy & Lactation

FDA Pregnancy Category C. Ciprofloxacin is generally not recommended during pregnancy unless the benefit clearly outweighs the risk. Excreted in breast milk — not recommended during breastfeeding.

Precautions & Warnings

Risk of tendinitis and tendon rupture, especially in patients over 60, those on corticosteroids, or those with organ transplants. May cause peripheral neuropathy — discontinue if symptoms of pain, burning, or weakness occur. Avoid excessive sun exposure (photosensitivity). Not recommended for use in children and adolescents for routine infections due to risk of arthropathy. Use with caution in patients with a history of seizures or CNS disorders.

Use in Special Populations

Reduce dose in severe renal impairment (GFR <30 mL/min). Use with caution in hepatic impairment. Safety in children not established for most indications.

Therapeutic Class

Fluoroquinolone antibiotic (4-Quinolone preparations)

Storage Conditions

Store below 30°C in a dry place, away from light. Keep out of the reach of children.

Disclaimer: This product information is for reference purposes only and does not substitute professional medical advice, diagnosis, or treatment. Always consult a registered physician or qualified healthcare professional before taking any medication.