Clotrim 5 gm Cream

Clotrim 5 gm Cream

DESCRIPTION

CLOTRIM (Clotrimazole) is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, moulds and bacteroids. CLOTRIM (Clotrimazole) is also active against certain gram-positive bacteria especially Staphylococci and Tricomonas. Like other imidazoles, CLOTRIM (Clotrimazole) alters the permeability of fungal cell walls by interfering with cell wall lipids. At fungi static levels the main effect is inhibition of ergosterol synthesis but at higher concentrations there is an additional mechanism of membrane damage unrelated to sterol synthesis.

COMPOSITION

CLOTRIM cream : Each gram cream contains clotrimazole USP 10 mg.

CLOTRIM Vaginal suppository : Each suppository contains clotrimazole BP 200 mg.

INDICATIONS

CLOTRIM Cream (Clotrimazole) is indicated for

 All fungal skin infections due to dermatophytes (e.g. Trichophyton species).

 All dermatomycoses due to yeasts (e.g. Candida species).

 Skin diseases due to moulds and other fungi.

These dermatomycoses and skin infections include ring worm (tinea), athletes foot, paronychia, pityriasis versicolor, erythrasma, intertrigo, fungal nappy rash, candida balanitis.

CLOTRIM Vaginal suppository (Clotrimazole) is used in candidal vaginitis.

DOSAGE AND ADMINISTRATION.

Cream: Cream should be thinly and evenly applied 2-3 times daily to the affected area and rubbed in gently. To help clear up infection completely and prevent relapse, treatment should be continued for at least two weeks after the disappearance of all signs of infections. If the feet are infected they should be thoroughly washed and dried, especially between the toes, before applying the cream.

Suppository: One suppository should be inserted intravaginally daily (preferably at night) for three consecutive days. The suppository should be inserted into the vagina, as high as possible. This is best achieved when lying back with legs bent up.

OR AS DIRECTED BY THE PHYSICIANS.

USE IN PREGNANCY & LACTATION

CLOTRIM (Clotrimazole) is very poorly absorbed into the blood and the body after application to the skin or the vagina. Studies in women in their second or third trimesters have demonstrated no ill effects. It is not known if CLOTRIM (Clotrimazole) is secreted in breast milk. CLOTRIM (Clotrimazole) suppository can be used during pregnancy, but only under the supervision of Physician.

USUAL PAEDIATRIC DOSE

Cream : See usual adult dose.

Suppository: Paediatric use is not recommended.

CONTRAINDICATIONS

Clotrimazole is contraindicated for patients who are hypersensitive to Clotrimazole.

PRECAUTIONS

Constituents of the vaginal suppository may be incompatible with rubber in both contraceptive condoms and diaphragms. During period this treatment won’t have good result. Avoid oral or ophthalmic use.

SIDE EFFECTS

Occasional skin irritation or burning sensation may occur in a very few cases which are not considered harmful.

SUPPLY

Clotrim Cream 5 g : Each pack has a tube containing 5 g cream.

Clotrim Cream 10 g : Each pack has a tube containing 10 g cream.

CLOTRIM vaginal suppository: Each box contains 13 suppositories in blister strip.