Glunor 850 mg Tablet

Glunor 850 mg Tablet — Metformin Hydrochloride

Overview

Glunor 850 mg Tablet is the intermediate-strength immediate-release metformin option from Eskayef Pharmaceuticals Ltd., intended for patients who have already tolerated lower-dose metformin and need a higher daily dose to reach glycemic targets, or who prefer fewer tablets per dose than the 500 mg strength. It delivers the same well-established biguanide mechanism with dosing flexibility for step-up titration.

Mechanism of Action

Metformin reduces hepatic glucose output by inhibiting gluconeogenesis, decreases intestinal glucose absorption, and enhances insulin sensitivity in peripheral tissues. Because it works independently of insulin secretion, it does not typically cause hypoglycemia when used as monotherapy, distinguishing it from insulin secretagogues such as sulfonylureas.

Indications

Glunor 850 mg is indicated for type 2 diabetes mellitus in patients requiring a higher per-tablet metformin dose for convenient twice-daily dosing, typically as a step up from the 500 mg strength once GI tolerance is established. It is used alone or in combination with other oral antidiabetics or insulin as directed by a physician.

Dosage and Administration

A common regimen is 850 mg once daily with the main meal, increasing if needed to 850 mg twice daily after 1–2 weeks based on tolerance and blood glucose response, up to a maximum of around 2550 mg/day (combination of strengths). Switching from 500 mg tablets to 850 mg tablets should be done under physician guidance, generally after the lower dose has been well tolerated for at least one to two weeks.

Contraindications

Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis (including diabetic ketoacidosis), and known hypersensitivity to metformin. Use cautiously in patients with hepatic dysfunction, heart failure with hemodynamic instability, or conditions causing tissue hypoxia.

Side Effects

Gastrointestinal effects (nausea, diarrhea, bloating, metallic taste) are the most frequently reported, and tend to be dose-related — patients moving up from 500 mg to 850 mg may notice a temporary increase in GI symptoms that usually settles within days. Reduced vitamin B12 absorption can occur with prolonged use. Lactic acidosis is rare and almost always linked to an underlying predisposing condition.

Drug Interactions

Use with iodinated contrast media requires temporary discontinuation of metformin as advised by the physician due to acute kidney injury risk. Alcohol use should be limited, as it can potentiate the effect of metformin on lactate metabolism. Inform your doctor of all other medications, including over-the-counter drugs and herbal supplements.

Special Precautions

Patients switching strengths should not simply substitute tablet-for-tablet between 500 mg and 850 mg products without physician guidance, since total daily metformin dose changes. Renal function should be checked at baseline and periodically. Temporary discontinuation is advised during acute illness with risk of dehydration or hypoxia.

Storage

Store below 30°C, away from direct light and moisture. Keep out of reach of children.

Frequently Asked Questions

Q1: Should I switch from Glunor 500 to Glunor 850 on my own?
No, any change in metformin strength or total daily dose should be directed by your physician based on your glycemic control and tolerance.

Q2: Will Glunor 850 cause more stomach upset than 500 mg?
Some patients notice slightly more GI discomfort when first stepping up in dose, but this typically improves within a few days, especially if taken with food.

Q3: Can Glunor 850 be split in half?
Tablet splitting should only be done if your physician or pharmacist confirms the tablet formulation allows it; do not split without guidance.

Q4: Is Glunor 850 suitable for elderly patients?
It can be used in elderly patients but with closer monitoring of renal function, as metformin clearance depends on kidney function which often declines with age.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.