Met 850 mg Tablet

Met 850 mg Tablet — Metformin Hydrochloride

Overview

Met 850 is a higher-strength metformin tablet from Opsonin Pharma Limited, intended for type 2 diabetes patients who require a stronger per-tablet dose than 500 mg to reach glycemic targets.

Mechanism of Action

Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves peripheral insulin sensitivity in muscle and adipose tissue, without directly stimulating pancreatic insulin secretion.

Indications

Met 850 is indicated for type 2 diabetes mellitus in patients requiring a higher metformin dose, typically introduced after the 500 mg strength has been well tolerated.

Dosage and Administration

A typical regimen starts at 850 mg once daily with a meal, increasing to twice daily after 1–2 weeks if tolerated, up to a maximum total daily dose of approximately 2550 mg.

Contraindications

Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis including diabetic ketoacidosis, and known hypersensitivity to metformin.

Side Effects

Gastrointestinal effects such as nausea, diarrhea, and abdominal discomfort are most common during initial dose step-up. Long-term use may reduce vitamin B12 absorption.

Drug Interactions

Iodinated contrast media require temporary discontinuation of metformin. Alcohol intake should be limited. Disclose all current medications and supplements to your physician or pharmacist.

Special Precautions

Renal function should be reassessed before stepping up to this higher strength and monitored periodically thereafter.

Storage

Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Frequently Asked Questions

Q1: When is Met 850 prescribed instead of Met 500?
It is typically prescribed when the 500 mg strength does not provide adequate glycemic control and has been well tolerated.

Q2: Does Met 850 cause more gastrointestinal side effects?
Some patients notice more discomfort initially when stepping up; taking it with food helps reduce this.

Q3: How is Met 850 typically dosed?
Often started once daily with a meal and increased to twice daily as tolerated, per physician guidance.

Q4: Can Met 850 be used long-term?
Yes, once an effective and well-tolerated dose is established, it is commonly used long-term.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.