Met XR 500 mg Tablet

Met XR 500 mg Tablet — Metformin Hydrochloride (Extended Release)

Overview

Met XR 500 is an extended-release metformin tablet from Opsonin Pharma Limited, designed for once-daily dosing convenience with steadier blood glucose control and generally improved gastrointestinal tolerability.

Mechanism of Action

Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves peripheral insulin sensitivity. The extended-release matrix releases the drug gradually, supporting once-daily dosing.

Indications

Met XR 500 is indicated for type 2 diabetes mellitus, particularly for patients who prefer once-daily dosing or who experience gastrointestinal side effects with immediate-release metformin.

Dosage and Administration

Typically taken once daily with the evening meal; extended-release tablets must be swallowed whole and never crushed, split, or chewed.

Contraindications

Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis including diabetic ketoacidosis, and known hypersensitivity to metformin.

Side Effects

Generally better gastrointestinal tolerability than immediate-release formulations, though nausea, diarrhea, or abdominal discomfort can still occur. Long-term use may reduce vitamin B12 absorption.

Drug Interactions

Iodinated contrast media require temporary discontinuation of metformin. Alcohol intake should be limited. Disclose all current medications and supplements to your physician or pharmacist.

Special Precautions

Patients may occasionally notice the tablet matrix in stool; this is expected and does not indicate reduced effectiveness. Renal function should be monitored periodically.

Storage

Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Frequently Asked Questions

Q1: What does "XR" mean for Met XR 500?
XR stands for extended release, meaning the tablet releases medication gradually over time to support once-daily dosing.

Q2: Why might my doctor switch me to Met XR instead of regular Met?
Extended-release formulations offer once-daily convenience and often cause fewer gastrointestinal side effects.

Q3: Can I crush Met XR 500 tablets?
No, extended-release tablets must be swallowed whole; ask your pharmacist about alternatives if swallowing is difficult.

Q4: Is it normal to see tablet remnants in my stool?
Yes, the inert tablet matrix may occasionally be visible in stool after the medication has been absorbed; this is not a cause for concern.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.