Terbin 250 mg tab

Introduction

Terbin 250 is used to treat a wide range of fungal infections of the skin and nails, including ringworm. It works by killing the fungus that causes the infection. Terbin 250 is for external use only. It should be used in the dose and duration suggested by the doctor. Applying it at the same time every day will help you remember to use it. The affected area should be clean and dry before application of the ointment. You must wash your hands thoroughly before and after applying this medicine. Do not stop using it until you have finished the complete course, even when you feel better. If you stop using this medicine too early, the fungus may continue to grow and the infection may return or worsen. The most common side effects of this medicine include application site reactions like burning, irritation, itching, and redness. These are usually mild but let your doctor know if they bother you or last more than a few days. Avoid direct contact with eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water. You must inform your doctor if there's no improvement even after four weeks of treatment. It is not likely that other medicines you take by mouth or injection will affect the way it works but talk to your doctor before using it if you have used a similar medicine before and had an allergic reaction. Pregnant and breastfeeding mothers should consult their doctor before using it.

Uses of Terbin 250

• Fungal skin infections

Side effects of Terbin 250

• Skin peeling

How to use Terbin 250

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Terbin 250 works

Terbin 250 is an antifungal medication which treats skin infections. It works by killing the fungi on the skin by destroying their cell membrane.

What if you forget to take Terbin 250?

If you miss a dose of Terbin 250, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Indication

Tinea pedis, Tinea cruris, Tinea corporis, Dermatophytosis, Nail infections

Administration

May be taken with or without food.

Adult Dose

Oral Onychomycosis Adult: 250 mg once daily for 6 weeks (fingernail) or 12 weeks (toenail) Tinea Pedis, Tinea Corporis, Tinea Cruris Adult: 250 mg/day PO in single dose or divided q12hr 2-4 wk in tinea cruris, tinea corporis 2-6 wk for tinea pedis Hepatic impairment: Use not recommended in chronic or active liver disease

Child Dose

Tinea Capitis >4 years (<25 kg): 125 mg/day PO for 6 weeks >4 years (25-35 kg): 187.5 mg/day PO for 6 weeks >4 years (>35 kg): 250 mg/day PO for 6 weeks

Renal Dose

Renal impairment: Use not recommended if CrCl <50 mL/min

Contraindication

Hypersensitivity, active or chronic liver disease, lactation.

Mode of Action

Terbinafine causes fungal cell death by inhibiting squalene epoxidase, the main enzyme in sterol biosynthesis, resulting in ergosterol deficiency within fungal cell walls. It has fungicidal activity against dermatophytes and some yeast.

Precaution

Preexisting liver or renal impairment, pregnancy. Perform liver function tests prior to oral therapy. Lactation: Drug excreted in breast milk; do not use

Side Effect

>10% Headache (13%) 1-10% Rash (6%),Pruritus (3%),Nausea (3%),Diarrhea (6%),Dyspepsia (4%),Abdominal pain (2%),Taste disturbance (3%),Elevated liver function test results (3%),Visual disturbance (1%) Potentially Fatal: Liver failure, Stevens-Johnson syndrome, neutropaenia.

Interaction

Possible increase in levels in drugs metabolised by CYP450 2D6. Decreased terbinafine concentration with rifampicin; increased terbinafine concentration with cimetidine.