Trulicity 0.75/0.5ml

Dulaglutide (Trulicity) Injection

Overview

Dulaglutide (brand name Trulicity) is a once-weekly injectable GLP-1 receptor agonist used to improve blood sugar control in adults with type 2 diabetes.

Mechanism of Action

Dulaglutide activates the GLP-1 receptor, increasing glucose-dependent insulin release from beta cells, decreasing glucagon secretion, and slowing gastric emptying.

Indications

Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes, and to reduce the risk of major cardiovascular events in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors.

Dosage and Administration

The recommended starting dose is 0.75 mg once weekly, which may be increased to 1.5 mg once weekly for additional glycemic control, up to a maximum of 1.5 mg weekly. It is injected subcutaneously into the abdomen, thigh, or upper arm, any time of day, with or without food.

Contraindications

Contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2.

Side Effects

Commonly reported effects include nausea, diarrhoea, vomiting, abdominal pain, and decreased appetite, particularly when starting treatment.

Drug Interactions

May affect absorption of oral medicines due to slowed gastric emptying; insulin or sulfonylurea combinations may increase hypoglycemia risk.

Special Precautions

Inject at the same time each week; if a dose is missed, follow your physician's guidance on the catch-up window. Report symptoms of pancreatitis (severe abdominal pain) immediately.

Storage

Store refrigerated at 2-8°C before first use; once in use, may be kept at room temperature per the manufacturer's instructions for a limited period. Do not freeze. Protect from light.

Frequently Asked Questions

Q1: How often is Dulaglutide injected?
It is a once-weekly injection, making it more convenient than daily insulin or oral regimens for many patients.

Q2: What should be done if a weekly dose is missed?
Follow the specific catch-up guidance from your physician or the product leaflet, which depends on how many days have passed since the missed dose.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.