A-Migel 30 gm Gel

A-Migel 30 gm Gel

Description

Miconazole is a synthetic imidazole anti-fungal agent with a broadspectrum of activity against pathogenic fungi (including yeast and dermatophytes) and gram-positive bacteria (Staphylococcus and Streptococcus spp). It may act by interfering with the permeability of the fungal cell membranes. Miconazole oral gel is incompletely absorbed from the gastrointestinal tract. Miconazole is inactivated in the body and 10-20% of an oral dose is excreted in the urine.

Composition

Each gram oral gel contains 20 mg Miconazole USP.

Indication

Oral treatment and prevention of fungal infections of the oropharynx and gastrointestinal tract.

Dosage and Administration

For oral administration : Dosage is based on 15 mg/kg/day after meal. Adults : 1-2 tea-spoonfuls of gel four times daily.

Children aged 6 years and over : One tea-spoonful of gel four times daily.

Children aged 2-6 years : One tea-spoonful of gel twice daily. Infants under 2 years : Half tea-spoonful of gel twice daily. For localised lesions of the mouth, a small amount of A-Migel oral gel may be applied directly to the affected area with a clean finger 2-4 times daily. For topical treatment of the oropharynx, the gel should be kept in the mouth for as long as possible. Treatment should be continued for up to 2 days after the symptoms have cleared. For oral candidiasis, dental prostheses should be removed at night and brushed with the gel.

OR AS DIRECTED BY THE PHYSICIAN

Side effects

Occasionally, nausea and vomiting have been reported and with long term treatment, diarrhoea is also reported.

Contraindications

Miconazole is contraindicated in patients with known hypersensitivity to the active drug and imidazole group.

Precaution

The concomitant use of Miconazole with anti-coagulant, anti-epileptic and anti-diabetic drugs increases the affectivity of these drugs. So dosage of Miconazole should be revised.

Use in Pregnancy & Lactation

In animals Miconazole has shown no teratogenic effects but is foetotoxic at high oral doses. However, as with other imidazoles, Miconazole Oral Gel should be avoided in pregnant women if possible. The potential hazards should be balanced against the possible benefits. It is not known whether Miconazole is excreted in human milk. Caution should be exercised when prescribing Miconazole Oral Gel to nursing mothers.

Over dosage

In general, Miconazole is not highly toxic. In the event of accidental over dosage, vomiting and diarrhoea may occur.

Supply

Oral Gel : Each carton contains 15 gm oral gel in tube and a spoon.