Bigmet 500 mg Tablet

Bigmet 500 mg Tablet — Metformin Hydrochloride

Overview

Bigmet 500 is manufactured by Renata Limited, one of Bangladesh's leading pharmaceutical companies, providing a standard-strength metformin tablet for first-line management of type 2 diabetes.

Mechanism of Action

Metformin lowers blood glucose primarily by reducing hepatic glucose production, decreasing intestinal glucose absorption, and improving insulin sensitivity in peripheral tissues, without stimulating pancreatic insulin release.

Indications

Bigmet 500 is indicated for type 2 diabetes mellitus as first-line therapy alongside diet and exercise, and can be used alone or in combination with other antidiabetic medications.

Dosage and Administration

The usual starting dose is 500 mg once or twice daily with meals, increased gradually as needed, with typical maintenance doses of 1500–2000 mg/day in divided doses.

Contraindications

Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis including diabetic ketoacidosis, and known hypersensitivity to metformin.

Side Effects

Common side effects include nausea, diarrhea, abdominal discomfort, and metallic taste, which are usually mild and improve with gradual dose titration. Long-term use may reduce vitamin B12 absorption.

Drug Interactions

Iodinated contrast media require temporary discontinuation of metformin. Alcohol intake should be limited. Disclose all current medications and supplements to your physician or pharmacist.

Special Precautions

Renal function should be assessed before starting therapy and monitored periodically, particularly in elderly patients.

Storage

Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Frequently Asked Questions

Q1: Who manufactures Bigmet?
Bigmet is manufactured by Renata Limited, a well-established pharmaceutical company in Bangladesh.

Q2: Should Bigmet 500 be taken with food?
Yes, taking it with or right after meals helps reduce gastrointestinal discomfort.

Q3: How long before Bigmet 500 shows results?
Some glucose-lowering effect may appear within days, but full benefit is usually evaluated after several weeks of regular use.

Q4: Can Bigmet 500 be combined with other diabetes medications?
Yes, metformin is frequently combined with other oral antidiabetics or insulin as directed by your physician.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.