Dermupin 10 gm Ointment

Dermupin 10 gm Ointment

Description

Mupirocin is a topical antibacterial agent, active against those organism responsible for the majority of the skin infections e.g. Staphylococcus aureus, including methicillin-resistant strains, other Staphylococci and streptococci. It is also active against Gram-negative pathogens, such as Escherichia coli and Haemophilus influenzae. Mupirocin is bactericidal at concentrations achieved by topical administration. However, the minimum bactericidal concentration (MBC) against relevant pathogens is generally eight-fold to thirty-fold higher than the minimum inhibitory concentration (MIC).

Composition: Each gram ointment contains Mupirocin USP 20 mg.

Indications

Dermupin Ointment is indicated for the topical treatment of impetigo due to Staphylococcus aureus and Streptococcus pyogenes.

Dosage and administration

A small amount of Dermupin Ointment should be applied to the affected area three times daily. The area treated may be covered with a gauze dressing if desired. Dermupin may be used for 10 days.

Side effects

The following local adverse reactions have been reported in connection with the use of Mupirocin ointment : burning, stinging, or pain in 1.5% of patients; itching in 1% of patients; rash, nausea, erythema, dry skin, tenderness, swelling, contact dermatitis, and increased exudate in less than 1% of patients.

Precautions

If a reaction suggesting chemical irritation should occur with the use of Mupirocin ointment, treatment should be discontinued and appropriate alternative therapy for the infection should be maintained. As with other antibacterial products, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. In common with other polyethylene glycolbased ointments, Mupirocin should not be used in caution if there is evidence of moderate or severe renal impairment.

Contraindications

This drug is contraindicated in individuals with a history of sensitivity reactions to any of its components.

Drug interactions : The effect of the concurrent application of Mupirocin and other drug products has not been studied.

Use in pregnancy and lactation

During Pregnancy : Because animal studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

During lactation : It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Mupirocin ointment is administered to a nursing woman.

Paediatric use

The safety and effectiveness of mupirocin have been established in the age range of 2 months to 16 years.

Overdose: No information available.

Supply:

Dermupin ointment: Tube contains 10 gm, 15 gm, 20 gm ointment.