Duo-5 LS TabDescriptionCefpodoxime-Clavulanic acid is a combination of two drugs and is effective against multiple infection types. Clavulanic acid component protects degeneration of cefpodoxime in presence of beta-lactamase enzymes and increases the antibiotic spectrum.Clavulanic acid in cefpodoxime-Clavulanic preparation preve... Read more →
Cefpodoxime-Clavulanic acid is a combination of two drugs and is effective against multiple infection types. Clavulanic acid component protects degeneration of cefpodoxime in presence of beta-lactamase enzymes and increases the antibiotic spectrum.
Clavulanic acid in cefpodoxime-Clavulanic preparation prevents the resistance to Cefpodoxime that may increase with continuous usage of the drug. It has shown effectiveness against multiple Gram-positive and Gram-negative bacteria and is generally well tolerated.
-Acute exacerbations of chronic bronchitis
-Acute community acquired pneumonia
-Uncomplicated urinary tract infections
General gonorrhea and rectal gonococcal infections.
Dosage & Administration
Pharyngitis or tonsillitis:- (Duo-5 LS) 100 mg 12 hourly for 5 to 10 days Uncomplicated urinary tract infections: (Duo-5 LS) 100 mg 12 hourly for 7 days Complicated urinary tract infections: (Duo-5) 200 mg 12 hourly for7 days Acute community acquired pneumonia: (Duo-5) 200 mg 12 hourly for 14 days Acute bacterial exacerbations of chronic bronchitis: (Duo-5) 200 mg 12 hourly for 10 days Uncomplicated gonorrhea and rectal gonococcal infections: (Duo-5) single dose Skin and skin structure infections: (Duo-5) 200-400 mg 12 hourly for 7 to 14 days Acute maxillary sinusitis: (Duo-5) 200 mg 12 hourly for 10 days Enteric fever: (Duo-5) 200 mg 12 hourly for 7 to 14 days Patients with renal dysfunction: For patients with severe renal impairment (< 30 ml/min creatinine clearance), the dosing intervals should be increased to 24 hourly. In patients maintained on hemodialysis, the dose frequency should be 3 times/week after hemodialysis. Patients with cirrhosis: Cefpodoxime pharmacokinetics in cirrhotic patients (with or without ascites) is similar to those in healthy subjects. Dose adjustment is not necessary in this population.
It has very few side effects. The side effects include diarrhoea, nausea, skin and vaginal fungal infection, vulvo-vaginal infections, abdominal pain and headache.
Cross hypersensitivity in penicillin sensitive patients, leading to serious acute hypersensitivity reactions may need treatment with epinephrine along with other emergency measures such as intravenous fluids, oxygen, airway management and intravenous antihistamine, as clinically indicated.
Use in Pregnancy & Lactation
Pregnancy Cefpodoxime is pregnancy category B. And Clavulanic acid is pregnancy category B.
Probenecid: Renal excretion of Cefpodoxime proxetil was inhibited by Probenecid and resulted in an approximately 31% increase in AUC. Nephrotoxic drugs: Close monitoring of renal function is advised when Cefpodoxime proxetil is administered concomitantly with compounds of known nephrotoxic potential.