Glarine 100 IU/ml Injection

Glarine 100 IU/ml – Insulin Glargine 10ml Vial by Incepta Pharmaceuticals

What is Glarine 10ml Vial?

Glarine 10ml is the larger-volume vial format of insulin glargine 100 IU/ml by Incepta Pharmaceuticals Ltd., Bangladesh. Containing 1,000 IU total, it is designed for patients with higher daily insulin requirements or those preferring a longer-lasting vial supply. Glarine contains the same insulin glargine molecule as the originator Lantus (Sanofi), providing a flat, peakless basal profile over approximately 24 hours. The larger 10ml vial format is economical for patients on stable once-daily glargine therapy using insulin syringes, and reduces the frequency of vial replacement.

Generic Name and Composition

Each ml: 100 IU insulin glargine (rDNA). Modified human insulin with A21 glycine substitution and two additional B30 arginine residues, shifting the isoelectric point to physiological pH. On SC injection, microprecipitation creates a sustained-release depot. Gradual dissolution delivers a flat, peakless insulin profile over ~24 hours — mimicking physiological basal secretion.

Indications

• Type 2 diabetes — once-daily basal insulin therapy
• Type 1 diabetes — basal component in basal-bolus regimen
• Adults and children aged 6 years and above
• High-dose patients or those on syringe-based delivery preferring 10ml economy format

How It Works — Mechanism of Action

Glarine forms an acidic clear solution at pH 4. On SC injection, pH neutralisation to 7.4 causes microprecipitation into stable glargine microcrystals. Slow dissolution releases insulin monomers steadily into the bloodstream over ~24 hours with no peak. Receptor activation promotes glucose uptake (GLUT-4), suppresses hepatic glucose production, and stimulates glycogen synthesis.

Dosage and Administration

Type 2 (insulin-naive): 10 IU once daily, titrate by 2 IU every 3 days. Type 1: Individualised; typically 40–50% of total daily dose. Draw up with U-100 insulin syringe. Inject SC (abdomen, thigh, upper arm). Do not mix with other insulins. Do not administer IV or IM.

Side Effects

Very common: Hypoglycaemia. Common: Injection site reactions, lipohypertrophy, weight gain, peripheral oedema. Uncommon: Lipoatrophy, visual changes at initiation. Rare: Generalised hypersensitivity, anaphylaxis.

Drug Interactions

Enhance hypoglycaemia: OADs, GLP-1 agonists, SGLT-2 inhibitors, ACE inhibitors, MAO inhibitors, salicylates, alcohol. Reduce effect: Corticosteroids, glucagon, thyroid hormones, sympathomimetics, thiazides, oral contraceptives. Mask symptoms: Beta-blockers, clonidine.

Contraindications

• Hypersensitivity to insulin glargine or excipients
• Active hypoglycaemia; IV/IM use; mixing with other insulins

Pregnancy and Lactation

Pregnancy: Consider human NPH insulin under specialist supervision. Lactation: No clinically significant infant exposure expected.

Precautions and Warnings

• Never mix with other insulins — disrupts pH-dependent microprecipitation.
• Rotate injection sites systematically.
• Glarine is a clear solution — discard if cloudy or particulate.
• Do not freeze. Protect from direct heat and sunlight.

Overdose

Hypoglycaemia. Mild: oral glucose. Severe: IV dextrose or IM glucagon 1mg. Monitor 2–4 hourly given ~24 hr duration.

Storage Instructions

• Unopened: 2–8°C. Do not freeze.
• In-use vial: Below 25°C, protected from light.
• Discard 28 days after first use.

Frequently Asked Questions

Q1: What is the difference between Glarine 3ml and Glarine 10ml?
Both contain insulin glargine 100 IU/ml by Incepta Pharmaceuticals. The 3ml vial holds 300 IU and suits patients with lower daily doses or those starting therapy. The 10ml vial holds 1,000 IU — more economical for patients on stable, higher-dose glargine therapy using insulin syringes, requiring less frequent vial changes.

Q2: Is Glarine interchangeable with Lantus?
Glarine contains the same glargine molecule at the same concentration (100 IU/ml). Clinically, the effect per unit is equivalent. Any switch between glargine brands should be done under medical supervision with blood glucose monitoring, as minor formulation differences can occasionally affect individual absorption.

Q3: Can I use Glarine 10ml with an insulin pen?
The standard 10ml vial requires an insulin syringe. Insulin pens use 3ml cartridges or pre-filled pen formats. If you prefer pen delivery, use the Glarine 3ml vial or ask about pen cartridge availability.

Q4: How do I dispose of the Glarine 10ml vial?
Once opened, discard after 28 days regardless of remaining insulin. Do not share vials between patients. Dispose of used vials and needles in a sharps container according to local medical waste guidelines.

Medical Disclaimer: For educational purposes only. Glarine is Rx-only. Consult your diabetologist before starting or changing insulin therapy. DiabetesStore.com.bd is a licensed online pharmacy in Bangladesh.