Metarin 500 mg Tablet

Metarin 500 mg Tablet — Metformin Hydrochloride

Overview

Metarin 500 is manufactured by Popular Pharmaceuticals Ltd., one of Bangladesh's leading pharmaceutical companies, offering a standard-dose metformin tablet for first-line type 2 diabetes management.

Mechanism of Action

Metformin lowers blood glucose by reducing hepatic glucose production, decreasing intestinal glucose absorption, and improving peripheral insulin sensitivity in muscle and fat tissue, without directly stimulating pancreatic insulin secretion.

Indications

Metarin 500 is indicated for type 2 diabetes mellitus as first-line therapy alongside diet and exercise, used alone or combined with other oral antidiabetic agents or insulin.

Dosage and Administration

The typical starting dose is 500 mg once or twice daily with meals, gradually titrated upward as tolerated, with maintenance doses commonly between 1500–2000 mg/day in divided doses.

Contraindications

Contraindicated in patients with severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis including diabetic ketoacidosis, and known hypersensitivity to metformin.

Side Effects

Common side effects include nausea, diarrhea, abdominal discomfort, and a metallic taste, usually mild and transient with continued use or gradual dose titration. Long-term use may reduce vitamin B12 absorption.

Drug Interactions

Iodinated contrast media require temporary discontinuation of metformin. Alcohol intake should be limited. Disclose all current medications and supplements to your physician or pharmacist.

Special Precautions

Renal function should be assessed before starting therapy and monitored periodically, particularly in elderly patients.

Storage

Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Frequently Asked Questions

Q1: How does Metarin 500 compare to other metformin brands available in Bangladesh?
Metarin, from Popular Pharmaceuticals, contains the same active ingredient as other metformin brands; brand choice often depends on physician preference and availability.

Q2: Should Metarin 500 be taken with food?
Yes, taking it with or just after meals helps minimize gastrointestinal discomfort.

Q3: How long before Metarin 500 starts working?
Some effect may be seen within days, but full benefit is typically assessed after several weeks of consistent use.

Q4: Will Metarin 500 cause low blood sugar (hypoglycemia)?
Metformin alone rarely causes hypoglycemia, though risk increases when combined with other antidiabetic medications.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.