Met XR 1000 mg Tablet

Met XR 1000 mg Tablet — Metformin Hydrochloride (Extended Release)

Overview

Met XR 1000 is the highest-strength extended-release metformin tablet from Opsonin Pharma Limited, intended for patients who need a higher total daily dose while retaining once-daily dosing convenience.

Mechanism of Action

Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves peripheral insulin sensitivity. The extended-release matrix releases the drug gradually, maintaining steadier blood levels.

Indications

Met XR 1000 is indicated for type 2 diabetes mellitus in patients requiring a higher metformin dose who prefer or tolerate once-daily extended-release dosing better than multiple immediate-release doses.

Dosage and Administration

Usually taken once daily with the evening meal; the maximum recommended dose of metformin extended-release formulations is generally 2000 mg/day. Tablets must be swallowed whole, never crushed or chewed.

Contraindications

Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis including diabetic ketoacidosis, and known hypersensitivity to metformin.

Side Effects

Generally well tolerated when initiated gradually from a lower strength; gastrointestinal symptoms such as nausea or diarrhea can still occur. Long-term use may reduce vitamin B12 absorption.

Drug Interactions

Iodinated contrast media require temporary discontinuation of metformin. Alcohol intake should be limited. Disclose all current medications and supplements to your physician or pharmacist.

Special Precautions

Renal function should be carefully assessed before prescribing this highest available strength and monitored periodically thereafter, especially in elderly or renally impaired patients.

Storage

Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Frequently Asked Questions

Q1: Who typically needs the 1000 mg extended-release strength?
Patients with higher metformin dose requirements who have already tolerated lower extended-release strengths well.

Q2: Is 1000 mg the maximum extended-release dose available?
It is at or near the upper limit for extended-release formulations; your physician will confirm the appropriate maximum for you.

Q3: Can this strength be split into smaller doses during the day?
Extended-release tablets are designed for once-daily dosing and should not be split unless specifically directed by your physician.

Q4: What should I do if I notice digestive discomfort at this strength?
Contact your physician, who may adjust the dose or timing; do not stop the medication abruptly without medical advice.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.