Met XR 750 mg Tablet

Met XR 750 mg Tablet — Metformin Hydrochloride (Extended Release)

Overview

Met XR 750 is an intermediate-strength extended-release metformin tablet from Opsonin Pharma Limited, bridging the gap between the 500 mg and 1000 mg XR strengths for patients needing finer dose titration.

Mechanism of Action

Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves peripheral insulin sensitivity. The extended-release matrix provides gradual drug release for once-daily dosing.

Indications

Met XR 750 is indicated for type 2 diabetes mellitus in patients who need a dose between the standard 500 mg and 1000 mg extended-release strengths.

Dosage and Administration

Usually taken once daily with the evening meal; tablets must be swallowed whole and never crushed, split, or chewed. Dose adjustments should only be made under physician supervision.

Contraindications

Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis including diabetic ketoacidosis, and known hypersensitivity to metformin.

Side Effects

Generally well tolerated; gastrointestinal symptoms such as nausea, diarrhea, or abdominal discomfort can occur, particularly during initial titration. Long-term use may reduce vitamin B12 absorption.

Drug Interactions

Iodinated contrast media require temporary discontinuation of metformin. Alcohol intake should be limited. Disclose all current medications and supplements to your physician or pharmacist.

Special Precautions

Renal function should be monitored periodically. Patients may occasionally notice the tablet matrix in stool; this is expected and does not indicate reduced effectiveness.

Storage

Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Frequently Asked Questions

Q1: Why would my doctor prescribe 750 mg instead of 500 mg or 1000 mg XR?
The 750 mg strength allows finer dose adjustment between the standard XR strengths to match individual glycemic response.

Q2: Can Met XR 750 be split in half?
No, extended-release tablets should be swallowed whole to maintain their controlled release properties.

Q3: When is the best time to take Met XR 750?
It is typically taken once daily with the evening meal, as directed by your physician.

Q4: What should I do if I experience persistent stomach upset?
Contact your physician, who may adjust your dose or switch you to a different strength or formulation.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.