- Stock: In Stock
- Brand: Acme Laboratories Limited
- Product ID: Ondansetron
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Periset 50 ml Oral Solution
DESCRIPTION
Ondansetron is a highly selective 5-HT3 receptor-antagonist. 5-HT3 serotonin receptors are present both peripherally on vagal nerve terminals and centrally in chemoreceptor trigger zone of the postrema. It is not certain whether ondansetron’s antiemetic action in chemotherapy-induced nausea and vomiting is mediated centrally, peripherally, or in both sites. However, cytotoxic chemotherapy appears to be associated with the release of serotonin from enterochromaffin cells of the small intestine.
COMPOSITION
Periset 50 ml Oral Solution: Each 5 ml contains Ondansetron Hydrochloride
USP equivalent to Ondansetron 4 mg.
INDICATIONS AND USES
• The prevention and treatment of Post-operative nausea and vomiting.
• The management of nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy.
SIDE EFFECTS
Generally Ondansetron is well tolerated. However few side effects including headache, diarrhoea, dizziness and constipation may be seen after
Ondansetron is administrated.
CONTRAINDICATIONS
Ondansetron is contraindicated for patients known to have hypersensitivity to the drug.
PRECAUTIONS
Ondansetron is not a drug that stimulates gastric or intestinal peristalsis. It should not be used instead of nasogastric suction. The use of Ondansetron in patients following abdominal surgery or in patients with chemotherapyinduced nausea and vomiting may mask a progressive ileus and/or gastric distension.
USE IN PREGNANCY & LACTATION
Pregnancy: Pregnancy category B.
Nursing Mother: It is not known whether Ondansetron is excreted in human milk. So, caution should be exercised when Ondansetron is administered to nursing women.
DRUG INTERACTIONS
There is no evidence that Ondansetron either induces or inhibits the metabolism of other drugs commonly coadministered with it. But
Ondansetron (HCl) is known to interact with other drugs like Carbamazepine, Phenytoin, Rifampicin and Tramadol.
OVERDOSAGE
There is no specific antidote for Ondansetron overdose. Hypertension (and
faintness) occurred in a patient that took 48 mg of Ondansetron.