Adarbi 40 mg Tablet, 1 Strip
Tk120
- Stock: In Stock
- Brand: NIPRO JMI Pharma Ltd.
- Product ID: Azilsartan Medoxomil
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Adarbi 40 mg Tablet, 1 Strip
Description:
Adarbi (Azilsartan Medoxomil), a prodrug, is hydrolyzed to Azilsartan in the gastrointestinal tract during absorption. Azilsartan is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan blocks the vasoconstrictor and aldosterone secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland.
Indication
Adarbi (Azilsartan Medoxomil) is indicated for the treatment of hypertension to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily stroke and myocardial infarction. Adarbi (Azilsartan Medoxomil) may be used either alone or in combination with other antihypertensive agents.
Dosage & Administration
The recommended dose in adults is 80 mg taken orally once daily. Consider a Starting dose of 40 mg for patients who are treated with high doses of diuretics. If blood pressure is not controlled with Adarbi alone, additional blood pressure reduction can be ahieved by taking Edarbi with other antihypertensive agents.
Contraindication
It is contraindicated to co-administer Aliskiren with Azilsartan in patients with Diabetes.
Precaution
Use of Azilsartan Medoxomil during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. In patients who are intravascularly volume-depleted (e.g., those treated with high-dose diuretics), symptomatic hypotension may occur. Changes in renal function including renal failure has been reported in renal impaired patient.
Side Effects
The most common adverse reaction in adults is diarrhea. The other side effects are nausea, asthenia, fatigue, muscle spasm, dizziness and cough.
Drug Interaction
No drug interactions have been observed in studies of Azilsartan Medoxomil or Azilsartan given with amlodipine, antacids, chlorthalidone, digoxin, fluconazole, glyburide, ketoconazole, metformin, pioglitazone and warfarin. The antihypertensive effect of Azilsartan may be attenuated by the non-steroidal anti-inflammatory drugs including selective COX-2 inhibitors. Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors or aliskiren is associated with increased risks of hypotension, hyperkalemia and changes in renal function.
Storage Condition
keep in a dry place away from light and heat. Keep out of the reach of children.
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