Amlopin 10 mg Tablet

Amlopin 10 mg Tablet

DESCRIPTION

AMLOPIN (Amlodipine) is 3rd generation a dihydropyridine calciumchannel blocker, with a long duration of action, used for the treatment of hypertension and angina pectoris. AMLOPIN (Amlodipine) influences the myocardial cells, the cells within the specialised conducting system of the heart, and the cells of vascular smooth muscle. Administration of AMLOPIN (Amlodipine) results primarily in vasodilation, with reduced peripheral resistance, blood pressure and afterload, increased coronary blood flow and a reflex increase in coronary heart rate. This in turn results in an increase in myocardial oxygen supply and cardiac output.

COMPOSITION

Tablet 5 : Each tablet contains Amlodipine INN (as Besylate) 5 mg.

Tablet 10 : Each tablet contains Amlodipine INN (as Besylate) 10 mg.

INDICATIONS

Hypertension : AMLOPIN is effective as monotherapy in the treatment of hypertension. It may be used in combination with other antihypertensive agents.

Angina pectoris : AMLOPIN is indicated for the treatment of chronic stable angina pectoris and is effective as monotherapy. It may be used in combination with other antianginal agents. Vasospastic angina : AMLOPIN is indicated for the treatment of confirmed or suspected vasospastic angina. It may be used as monotherapy or in combination with other antianginal drugs.

DOSAGE AND ADMINISTRATION

Hypertension : Usual dose is 5 mg once daily. Maximum dose is 10 mg once daily.

Elderly individuals and patients with hepatic insufficiency may be started on 2.5 mg once daily; this dose may also be used when adding AMLOPIN to other antihypertensive therapy. Angina (Chronic stable or vasospastic) : 5-10 mg, using the lower dose for elderly and in patients with hepatic insufficiency. Most patients require 10 mg.May be taken without regard to meals.

OR AS DIRECTED BY THE PHYSICIAN.

SIDE EFFECTS

The commonest side effects of Amlodipine are associated with the vasodilatory action, such as dizziness, flushing, headache, hypotension and peripheral oedema. Gastrointestinal disturbances, increased micturition frequency, lethargy, eye pain and mental depression may also occur. A paradoxical increase in ischaemic chest pain may occur at the start of the treatment and in a few patients excessive fall in blood pressure has led to cerebral or myocardial ischaemia or transient blindness. Rashes, fever and abnormalities in liver function due to hypersensitivity reaction of Amlodipine may occur.

PRECAUTIONS

Precaution should be taken in patients with hepatic impairment, during pregnancy and breast feeding.

DRUG INTERACTIONS

Potentially hazardous interactions : Little or no data is available in patients with markedly impaired cardiac left ventricular function; however, as with other calcium antagonist drugs, the combination of Amlodipine and b-blockers should be avoided in such patients. Other significant interactions : Digoxin : Absence of any interaction between Amlodipine and Digoxin in healthy volunteers has been documented in a controlled clinical study. Cimetidine : No interaction between Amlodipine and Cimetidine in healthy volunteers has been noted. Warfarin : Amlodipine did not significantly alter the effect of warfarin on prothrombin time. Food : Food does not alter the rate or extent of absorption of Amlodipine.

CONTRAINDICATIONS

Hypersensitivity to dihydropyridine derivatives. Pregnant woman.

SUPPLY

Tablet 5 : Each box contains 3 X 10 tablets in blisters.

Tablet 10 : Each box contains 3 X 10 tablets in blisters.