- Stock: Out Of Stock
- Brand: Acme Laboratories Limited
- Product ID: Metformin Hydrochloride
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Daomin XR 1000 mg Tablet — Metformin Hydrochloride (Extended Release)
| Generic Name | Metformin Hydrochloride (Extended Release) |
|---|---|
| Strength | 1000 mg |
| Dosage Form | Extended-Release Tablet |
| Manufacturer | The ACME Laboratories Ltd. |
| Therapeutic Class | Biguanide — Oral Antidiabetic (Extended Release) |
| Pack Size | Standard Strip/Box |
Overview
Daomin XR 1000 mg is the highest-strength extended-release metformin tablet in the Daomin range, intended for patients with higher total daily metformin requirements who benefit from fewer tablets per dose while retaining once-daily dosing convenience.
Mechanism of Action
The extended-release matrix gradually releases metformin over several hours, smoothing plasma concentrations compared to immediate-release tablets. At this highest strength, the same core mechanisms apply — reduced hepatic glucose output, decreased intestinal absorption, and improved peripheral insulin sensitivity — delivered in a more concentrated per-tablet dose.
Indications
Daomin XR 1000 mg is indicated for type 2 diabetes mellitus in patients who have been titrated up from lower XR strengths and require a higher total daily metformin dose with continued once-daily convenience.
Dosage and Administration
This strength is typically reached only after gradual titration from lower XR doses, with the total daily dose generally not exceeding 2000 mg once daily. Tablets must be swallowed whole and never crushed, split, or chewed.
Contraindications
Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis including diabetic ketoacidosis, and known hypersensitivity to metformin. Caution is advised at this higher strength in patients with borderline renal function.
Side Effects
While extended-release formulations generally cause fewer gastrointestinal effects, nausea or diarrhea can still occur, especially if this strength was reached too quickly. Long-term use may reduce vitamin B12 absorption.
Drug Interactions
Iodinated contrast media require temporary discontinuation of metformin. Alcohol intake should be limited. Disclose all current medications and supplements to your physician or pharmacist.
Special Precautions
Renal function should be closely monitored at this higher strength, particularly in elderly patients or those with borderline kidney function. Do not increase to this dose without physician guidance.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Frequently Asked Questions
Q1: Is Daomin XR 1000 mg a starting dose?
No, it is typically a maintenance dose reached after gradual titration from lower extended-release strengths.
Q2: Why might my doctor prefer one 1000 mg tablet over two 500 mg tablets?
A single higher-strength tablet can simplify the dosing regimen and improve adherence.
Q3: What monitoring is recommended at this higher strength?
Periodic renal function testing and routine glycemic monitoring are recommended, especially in older patients.
Q4: Can this strength be taken more than once daily?
Maximum extended-release metformin dosing is generally capped around 2000 mg/day once daily; consult your physician before any higher regimen.
Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.
