Informet 850 mg Tablet

Informet 850 mg Tablet — Metformin Hydrochloride

Overview

Informet 850 mg from Beximco Pharmaceuticals Ltd. delivers a higher per-tablet metformin dose, suitable for patients who require greater glycemic control than the 500 mg strength provides while keeping pill count manageable.

Mechanism of Action

Metformin reduces hepatic glucose output, decreases intestinal glucose absorption, and improves peripheral insulin sensitivity. This mechanism is consistent across strengths; the 850 mg tablet simply delivers more active drug per dose.

Indications

Informet 850 mg is indicated for type 2 diabetes mellitus in patients requiring a higher metformin dose, typically after demonstrated tolerance to lower strengths.

Dosage and Administration

A typical regimen is 850 mg once daily with a meal, increasing to twice daily after 1–2 weeks if tolerated, with a maximum total daily metformin dose generally around 2550 mg.

Contraindications

Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²), metabolic acidosis including diabetic ketoacidosis, and known hypersensitivity to metformin.

Side Effects

Gastrointestinal effects such as nausea, diarrhea, and abdominal discomfort are most common during the initial step-up period. Long-term use may reduce vitamin B12 absorption.

Drug Interactions

Iodinated contrast media require temporary discontinuation of metformin. Alcohol intake should be limited. Disclose all current medications and supplements to your physician or pharmacist.

Special Precautions

Renal function should be reassessed before stepping up to this higher strength and monitored periodically thereafter.

Storage

Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Frequently Asked Questions

Q1: When would my doctor prescribe Informet 850 instead of 500?
It is typically prescribed when the 500 mg dose does not provide adequate glycemic control and metformin has been well tolerated.

Q2: Does the higher strength cause more side effects?
Some patients experience more gastrointestinal discomfort during the initial step-up; taking it with food helps.

Q3: Can Informet 850 be split in half?
Do not split or crush tablets unless specifically advised by your physician or pharmacist.

Q4: Is Informet 850 suitable for long-term maintenance?
Yes, once an effective and well-tolerated dose is established, it is commonly used for long-term therapy.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.