- Stock: In Stock
- Brand: Square Pharmaceuticals
- Product ID: Linagliptin + Metformin Hydrochloride
100% Secure Payment
bKash | Nagad | Cards via SSLCommerz | COD
Monthly Medicines Available | Free Delivery on Eligible Orders
| Generic Name | Linagliptin + Metformin Hydrochloride |
|---|---|
| Strength | 2.5 mg + 500 mg |
| Dosage Form | Tablet |
| Manufacturer | Square Pharmaceuticals PLC |
| Therapeutic Class | Combination Oral Hypoglycemic Preparations |
| Pack Size | 5 × 6 tablets (30 tablets per pack) |
Overview
Liglimet Tablet is a fixed-dose combination of Linagliptin and Metformin Hydrochloride, manufactured by Square Pharmaceuticals PLC. It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both components is appropriate. Linagliptin works by inhibiting DPP-4, thereby increasing active incretin hormone levels, while Metformin reduces hepatic glucose production and improves insulin sensitivity.
Dosage and Administration
Dosage of Liglimet should be individualized based on effectiveness and tolerability. The maximum recommended dose is 2.5 mg Linagliptin + 1000 mg Metformin Hydrochloride twice daily, taken with meals. For patients not currently on Metformin, initiate with 2.5 mg Linagliptin + 500 mg Metformin twice daily. For patients already on Metformin, start with 2.5 mg Linagliptin combined with the current Metformin dose twice daily. Dose escalation should be gradual to reduce gastrointestinal side effects. Always take with food to minimize GI intolerance.
Interaction
Cationic drugs excreted by renal tubular secretion (e.g., amiloride, digoxin, morphine, procainamide, quinidine, ranitidine, trimethoprim, vancomycin) may interact with Metformin. Carbonic anhydrase inhibitors (e.g., topiramate, zonisamide) may increase the risk of lactic acidosis. Strong P-glycoprotein and CYP3A4 inducers (e.g., rifampin) may reduce Linagliptin efficacy — alternative treatments not containing Linagliptin are strongly recommended in such cases. Drugs that produce hyperglycemia (thiazide diuretics, corticosteroids, estrogens, phenytoin, sympathomimetics) may impair glycemic control.
Contraindications
Liglimet is contraindicated in patients with renal impairment due to the risk of Metformin accumulation and lactic acidosis. It is also contraindicated in acute or chronic metabolic acidosis (including diabetic ketoacidosis) and in patients with known hypersensitivity to Linagliptin or Metformin Hydrochloride.
Side Effects
The most common side effects are nasopharyngitis and diarrhea. Hypoglycemia is more common when Liglimet is used in combination with sulfonylureas. Metformin may lower Vitamin B12 levels with prolonged use. Rare but serious risks include lactic acidosis and acute pancreatitis.
Pregnancy and Lactation
There are no adequate and well-controlled studies in pregnant women with Liglimet or its individual components. It should be used during pregnancy only if clearly needed. Caution should be exercised when administering to a lactating mother, as it is not established whether the combination is safe for nursing infants.
Precautions and Warnings
If lactic acidosis is suspected in a patient taking Metformin, the drug should be discontinued immediately and supportive therapy instituted. Liglimet should be temporarily discontinued before radiologic studies involving intravascular iodinated contrast agents and before major surgical procedures requiring restricted food and fluid intake. Monitor for acute pancreatitis — if suspected, discontinue immediately. Annual monitoring of hematologic parameters is recommended due to the potential for Metformin to lower Vitamin B12 levels. Avoid excessive alcohol intake. Patients should carry identification indicating their diabetes status and medication regimen.
Storage Conditions
Store in a cool and dry place below 30°C, protected from light and moisture. Keep out of the reach of children.
Frequently Asked Questions
Q: What is Liglimet 2.5 mg + 500 mg Tablet used for?
A: Liglimet is a combination antidiabetic tablet used to improve blood sugar control in adults with type 2 diabetes mellitus, as an adjunct to diet and exercise, when treatment with both Linagliptin and Metformin is appropriate.
Q: When should Liglimet be taken?
A: Liglimet tablets should be taken with meals to reduce gastrointestinal side effects. The usual starting dose is one tablet (2.5 mg + 500 mg) twice daily; the dose may be adjusted by the physician based on glycemic response and tolerability.
