- Stock: In Stock
- Brand: Renata
- Product ID: Esomeprazole Magnesium Trihydrate
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Maxpro MUPS MUPS Tablet — Esomeprazole
| Generic Name | Esomeprazole |
|---|---|
| Strength | 20 mg |
| Dosage Form | Tablet |
| Manufacturer | Renata Limited |
| Therapeutic Class | Proton Pump Inhibitor |
Indications
Adults (from the age of 18 years)-Gastroesophageal reflux disease (GERD):
Non-erosive reflux disease (NERD) (i.e. heartburn and regurgitation),
Maintenance treatment of NERD (i.e. heartburn and regurgitation),
Reflux esophagitis or erosive esophagitis, ... Read moreAdults (from the age of 18 years)-Gastroesophageal reflux disease (GERD):
Non-erosive reflux disease (NERD) (i.e. heartburn and regurgitation),
Maintenance treatment of NERD (i.e. heartburn and regurgitation),
Reflux esophagitis or erosive esophagitis,
Maintenance treatment of patients with reflux esophagitis
Healing of NSAID associated gastric ulcersReduction of risk of NSAID associated gastric ulcersZollinger-Ellison SyndromeH. pylori eradicationPediatrics (12-17 years of age)-
Gastroesophageal reflux disease (GERD)
Non-erosive reflux disease (NERD) (i.e. heartburn and regurgitation)
Reflux esophagitis or erosive esophagitis.
Mechanism of Action
The proton pump inhibitor Esomeprazole inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system (the proton pump) of the gastric parietal cell. Proton pump inhibitors are effective for short-term treatment of gastric and duodenal ulcers. Esomeprazole is also used in the prevention and treatment of NSAID associated gastric ulcers.
Contraindications
Esomeprazole is contraindicated in patient with known hypersensitivity to any of the formulation.
Side Effects
The most common side effects of Maxpro MUPS are nausea, vomiting, abdominal pain, flatulence, diarrhea, constipation and headache. Less frequent side effects include dry mouth, peripheral edema, dizziness, sleep disturbances, fatigue, paraesthesia, arthralgia, myalgia, rash and pruritus. Other side effects reported rarely or very rarely include taste disturbance, stomatitis, hepatitis, jaundice, hypersensitivity reactions (including anaphylaxis, bronchospasm), fever, depression, hallucinations, confusion, gynaecomastia, interstitial nephritis, hyponatraemia, blood disorders (including leucopenia, leukocytosis, pancytopenia, thrombocytopenia), visual disturbances, sweating, photosensitivity, alopecia, Stevens-Johnson Syndrome and toxic epidermal necrolysis.
Drug Interactions
Maxpro MUPS is extensively metabolized in the liver by CYP2C19 and CYP3A4. In vitro and in vivo studies have shown that Maxpro MUPS is not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4. No clinically relevant interactions with drugs metabolized by these CYP enzymes would be expected. Drug interaction studies have shown that Maxpro MUPS does not have any clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin. Maxpro MUPS may potentially interfere with CYP2C19, the major Maxpro MUPS metabolizing enzyme. Co-administration of Maxpro MUPS 30 mg anddiazepam, a CYP2C19 substrate has resulted in a 45% decrease in clearance of diazepam. Increased plasma levels of diazepam have been observed 12 hours after dosing and onwards. Maxpro MUPS inhibits gastric acid secretion. Therefore, Maxpro MUPS may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g., ketoconazole, iron salts and digoxin). Co-administration of oral contraceptives, diazepam, phenytoin, or quinidine do not seem to change the pharmacokinetic profile of Maxpro MUPS. Combination Therapy with Clarithromycin: Co-administration of Maxpro MUPS, clarithromycin, and amoxicillin has resulted in increases in the plasma levels of Maxpro MUPS and 14-hydroxyclarithromycin.
Pregnancy and Lactation
Pregnancy: For esomeprazole, limited clinical data on exposed pregnancies are available. Esomeprazole should only be given to pregnant women if its use is considered essential.Lactation: It is not known whether esomeprazole is excreted in breast milk. Therefore esomeprazole should not be used during breast-feeding.
Precautions and Warnings
Maxpro MUPS should be used carefully if the patient has severe liver dysfunction and severe renal impairment. Taking a proton pump inhibitor like Maxpro MUPS may slightly increase the risk of hip, wrist and spine fracture, particularly when it is taken over a period of more than one year.
Overdose
There is very limited experience to date with deliberate overdose. The symptoms described in connection with 280 mg were gastrointestinal symptoms and weakness. Single doses of 80 mg Maxpro MUPS were uneventful. No specific antidote is known. Maxpro MUPS is extensively plasma protein bound and is therefore not readily dialyzable. As in any case of overdose, treatment should be symptomatic and general supportive measures should be utilized.
Storage
Store in a cool & dry place below 25ºC, protect from light. Keep out of reach of children.
Medical Disclaimer: This information is provided for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare professional before starting, changing, or stopping any medication.
