Naproxen 500

Naproxen 500 (Sodium) Tablet

Overview

Naproxen Sodium is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief and inflammation in conditions such as arthritis and musculoskeletal disorders.

Mechanism of Action

Naproxen blocks cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis, which underlies its analgesic, antipyretic, and anti-inflammatory effects.

Indications

Indicated for rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis, as well as general analgesia and acute musculoskeletal pain.

Dosage and Administration

For arthritis-type conditions in adults: 500-1000 mg per day in two divided doses 12 hours apart. For acute pain: an initial 500 mg dose, followed by 250 mg every 6-8 hours as needed. For juvenile rheumatoid arthritis in children over 2 years: 10 mg/kg/day in two divided doses.

Contraindications

Contraindicated in active peptic ulcer disease, known NSAID hypersensitivity, and in the third trimester of pregnancy.

Side Effects

Common effects include stomach upset, heartburn, and increased risk of gastrointestinal bleeding with prolonged use; cardiovascular risk may also be increased with long-term high-dose use.

Drug Interactions

Increases bleeding risk when combined with anticoagulants; may reduce the effectiveness of certain blood pressure medicines; avoid combining with other NSAIDs.

Special Precautions

Take with food to reduce stomach irritation. Use the lowest effective dose for the shortest duration, particularly in patients with cardiovascular or gastrointestinal risk factors.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Frequently Asked Questions

Q1: Should Naproxen be taken with food?
Yes, taking it with food or milk can help reduce the risk of stomach irritation.

Q2: Is Naproxen safe for long-term daily use?
Long-term use should be supervised by a physician due to potential gastrointestinal and cardiovascular risks, especially in older adults.

Medical Disclaimer: This information is provided for educational purposes only and does not replace professional medical advice. Always consult a registered physician or pharmacist before starting, stopping, or changing any medication. Dosage and suitability vary by individual health condition.