- Stock: In Stock
- Brand: NIPRO JMI Pharma Ltd.
- Product ID: Lactulose
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Niprolac Oral Solution 200 ml
Niprolac Oral Solution 100 ml
Description:
Niprolac (Lactulose) is a synthetic disaccharide. Lactulose is metabolized in the colon by the saccharolytic bacteria, producing low molecular weight organic acids (mainly lactic acid), which lowers the pH of the colon contents, promote the retention of water by an osmotic effect; thus increasing peristaltic activity. Lactulose is minimally absorbed; therefore, the pharmacokinetics of the absorbed material are not relevant to the principal therapeutic action.
Indication
2. Intestinal flora disturbances: In -damaged to intestinal flora (e.g. following long-term antibiotic treatment)
-gall bladder diseases
-intestinal diseases ( Colitis, Diverticulosis, Megacolon)
3. Increased blood ammonia levels (hyper ammoniemia in hepatopathy, portal-systemic encephalopathy)
Description:
Niprolac (Lactulose) is a synthetic disaccharide. Lactulose is metabolized in the colon by the saccharolytic bacteria, producing low molecular weight organic acids (mainly lactic acid), which lowers the pH of the colon contents, promote the retention of water by an osmotic effect; thus increasing peristaltic activity. Lactulose is minimally absorbed; therefore, the pharmacokinetics of the absorbed material are not relevant to the principal therapeutic action.
Indication
1. Constipation (Chronic Constipation): In every case of chronic constipation, initial treatment should consist of a diet rich in fiber (vegetables, salads, fruits etc.) a generous amount of liquids and much physical exercise. Niprolac is only to be taken when these measures prove insufficient.
2. Intestinal flora disturbances: In -damaged to intestinal flora (e.g. following long-term antibiotic treatment)
-gall bladder diseases
-intestinal diseases ( Colitis, Diverticulosis, Megacolon)
3. Increased blood ammonia levels (hyper ammoniemia in hepatopathy, portal-systemic encephalopathy)Dosage & Administration
Dosage should be followed accurately unless otherwise specified. 1. In constipation ( chronic constipation):
Adults :
Initially: 3-6 tea spoons daily
In long-term Therapy: 11/2-6 tea spoons daily
Children up to 14 years: Initially: 3 tea spoons daily
In long-term Therapy: 1-2 tea spoons daily
Infants & toddlers:
Initially: 1-2 tea spoons daily
In long-term Therapy: 1 tea spoons daily
2. In damaged intestinal flora:
Adults: 1-2 tea-spoons daily
Children: 1 tea-spoon daily
3. For reduction of blood ammonia level: Hyper-ammoniemia in hepatopathy- a maximum of 18-30 tea-spoons daily. In portal systemic encephalopathy- hourly doses of 6-9 tea-spoons of Lactulose solution may be used to induce the rapid laxation. When the laxative effect has been achieved, the dose may then be reduced.Contraindication
Hypersensitivity to either galactose and or lactose; galactose-free diet, gastro-cardial symptom complex, suspected intestinal obstructionPrecaution
Niprolac should be administered with care to patients who are intolerant to lactulose. The dose used in the treatment of (pre) coma hepaticum is usually much higher and may need to be taken into consideration for diabetics.Side Effects
Occasionally flatulence, cramp and abdominal discomfort can occur at the beginning of treatment; this is rapidly eliminated by reducing the dose. Overdose can result in diarrhoea. In abuse, loss of electrolytes (primarily potassium).Drug Interaction
There is no significant drug interactions with lactulose. The glycosidic effect of cardiac glycosides can be intensified by potassium deficiency in abusePregnancy & Lactation
US FDA Pregnancy Category of Lactulose is B. Studies show that Lactulose has no adverse effects. Decisions regarding use during pregnancy and lactation must be made by registered physician.Storage Condition
Keep in a dry place away from light and heat. Keep out of the reach of children.