- Stock: Out Of Stock
- Brand: Acme Laboratories Limited
- Product ID: Oxyphenonium Bromide
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A Spasm 5 mg Tablet (Oxyphenonium Bromide) — Product Overview
| Quick Reference | |
|---|---|
| Brand Name | A Spasm |
| Generic Name | Oxyphenonium Bromide 5 mg |
| Drug Class | Anticholinergic / Antispasmodic |
| Manufacturer | ACI Limited, Bangladesh |
| Dosage Form | Tablet |
| Strength | 5 mg per tablet |
| Storage | Below 25°C, in a dry place away from light |
| Prescription Status | Prescription Required |
What is A Spasm (Oxyphenonium Bromide)?
A Spasm contains Oxyphenonium Bromide 5 mg, an anticholinergic antispasmodic agent used to relieve smooth muscle spasms in the gastrointestinal and urinary tracts. It belongs to the quaternary ammonium class of anticholinergics, which means it has limited CNS penetration and primarily acts peripherally. A Spasm is widely prescribed for conditions involving cramping abdominal pain, irritable bowel syndrome (IBS), peptic ulcer disease, and other conditions associated with visceral spasm.
Mechanism of Action
Oxyphenonium Bromide works by competitively antagonising muscarinic acetylcholine receptors (primarily M1 and M3) in smooth muscle of the GI tract, biliary system, and urinary bladder. By blocking these receptors, it inhibits acetylcholine-mediated smooth muscle contractions, thereby reducing spasm, cramping, and excessive secretion. Its quaternary ammonium structure limits blood-brain barrier penetration, reducing central anticholinergic side effects compared to tertiary agents.
Indications
A Spasm is indicated for:
- Irritable Bowel Syndrome (IBS): Relief of cramping abdominal pain and intestinal spasm
- Peptic ulcer disease: Adjunct therapy to reduce gastric acid secretion and gastric motility
- Biliary colic: Relief of spasm in the biliary tract
- Renal colic: Adjunct to reduce ureteric spasm
- Spastic colon / colitis: Relief of bowel hypermotility
- Dysmenorrhoea: Uterine spasm and cramping pain during menstruation
- Urinary urgency / bladder spasm: Overactive bladder symptoms
Dosage and Administration
Adults: 5 mg (1 tablet) 3–4 times daily, taken 30 minutes before meals and at bedtime.
Elderly: Start with lower doses (2.5 mg 3–4 times daily) due to increased sensitivity to anticholinergic effects.
Children: Use under medical supervision only; dose adjusted by body weight.
Maximum dose: Do not exceed 30 mg per day without medical advice.
Take with a glass of water. May be taken with or without food. For peptic ulcer treatment, best taken 30 minutes before meals.
Contraindications
- Glaucoma (narrow-angle) — anticholinergics increase intraocular pressure
- Urinary retention or bladder neck obstruction
- Myasthenia gravis
- Paralytic ileus or gastric atony
- Pyloric stenosis
- Hypersensitivity to oxyphenonium bromide
- Severe ulcerative colitis / toxic megacolon
Side Effects
Common (anticholinergic effects): Dry mouth, reduced sweating, constipation, urinary hesitancy, blurred vision (especially near vision), increased heart rate (tachycardia).
Less common: Nausea, vomiting, dizziness, headache, skin flushing.
Rare: Urinary retention, confusion (more common in elderly), paralytic ileus at high doses.
The peripheral selectivity of oxyphenonium bromide means CNS effects (confusion, hallucinations) are less common than with tertiary anticholinergics like atropine.
Precautions
- Elderly patients: Use with caution — increased risk of confusion, urinary retention, constipation, and falls
- Prostatic hypertrophy: May cause urinary retention; use with caution
- Cardiovascular disease: Tachycardia effect may worsen certain cardiac conditions
- Hot weather / fever: Reduced sweating can cause heat stroke — take precautions
- Driving: May cause blurred vision or dizziness; use caution when driving
Frequently Asked Questions (FAQ)
Q: What is A Spasm tablet used for?
A: A Spasm (Oxyphenonium Bromide 5mg) is used to relieve abdominal cramps and spasms in conditions like IBS, peptic ulcer, biliary colic, and dysmenorrhoea. It relaxes smooth muscles in the gut and urinary tract.
Q: How quickly does A Spasm work?
A: Oxyphenonium bromide typically begins working within 30–60 minutes of oral administration. For best results with meal-related symptoms, take 30 minutes before eating.
Q: Can A Spasm be taken long-term?
A: It can be used for chronic conditions like IBS under medical supervision. For short-term colic, use as needed. Regular review by a doctor is recommended for long-term use.
Q: Why is my mouth dry after taking A Spasm?
A: Dry mouth is a very common anticholinergic side effect. Drinking plenty of water, chewing sugar-free gum, or using saliva substitutes can help manage this symptom.
Medical Disclaimer
The information provided is for educational purposes only. Always consult a qualified healthcare professional before using any medication. Do not use A Spasm without medical advice if you have glaucoma, urinary problems, or bowel obstruction.
