Kovicin 200 mg Tab

Kovicin 200 mg — Composition & Pharmacology

Generic Name: Hydroxychloroquine Sulfate
Manufacturer: Beximco Pharmaceuticals Ltd.
Drug Class: Antimalarial / Immunomodulatory Agent
Dosage Form: Tablet
Strength: 200 mg

Hydroxychloroquine is a 4-aminoquinoline compound with antimalarial and immunomodulatory properties. It accumulates in lysosomes, interfering with lysosomal function and antigen processing. It inhibits toll-like receptor signaling and reduces cytokine production, providing anti-inflammatory effects.

Indications

• Prophylaxis and treatment of malaria (Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum)
• Systemic Lupus Erythematosus (SLE) — disease modification
• Rheumatoid arthritis — as a disease-modifying antirheumatic drug (DMARD)
• Discoid lupus erythematosus

Dosage & Administration

Malaria treatment: 800 mg (as sulfate) initially, then 400 mg at 6, 24, and 48 hours. Malaria prophylaxis: 400 mg once weekly, beginning 1–2 weeks before exposure. SLE/RA: 200–400 mg/day (not exceeding 5 mg/kg/day). Take with food or milk.

Contraindications & Precautions

• Hypersensitivity to hydroxychloroquine, chloroquine, or 4-aminoquinolines
• Pre-existing retinopathy
• G6PD deficiency
• Prolonged QTc interval

Side Effects

Common (long-term use): GI disturbances, headache, skin rash, pruritus. Serious: irreversible retinopathy (dose-dependent — regular eye examinations required), QTc prolongation, cardiomyopathy, blood dyscrasias.

Drug Interactions

QTc-prolonging drugs: additive risk of arrhythmias. Antacids: reduced hydroxychloroquine absorption. Digoxin: increased plasma levels. Insulin/antidiabetics: may potentiate hypoglycaemic effect.

Storage

Store below 30°C, away from moisture and direct sunlight. Keep out of reach of children.

Medical Disclaimer: This information is for reference purposes only and is not a substitute for professional medical advice. Kovicin is a prescription/pharmacy medicine. Always consult a qualified physician or pharmacist before use. Self-medication can be harmful. Diabetesstore.com.bd strongly recommends obtaining a valid prescription for this medication.