- Stock: In Stock
- Brand: NIPRO JMI Pharma Ltd.
- Product ID: Linagliptin + Metformin Hydrochloride
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Lijenta-MX 5 mg+1000 mg Tablet, 1 Strip
Description:
PHARMACOLOGY
Linagliptin is an inhibitor of DPP-4 (dipeptidyl peptidase-4), an enzyme that degrades the incretin hormones GLP-1 (glucagon like peptide-1) and GIP (glucose dependent insulinotropic polypeptide). Thus, Linagliptin increases the concentrations of active incretin hormones, stimulating the release of insulin from pancreatic beta (?) cells in a glucose-dependent manner and decreasing the secretion of glucagon from pancreatic alpha (?) cells in the circulation.
Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity by an increase in peripheral glucose uptake and utilization. Thus, Metformin Hydrochloride lowers both basal and postprandial plasma glucose.
Indication
Dosage & Administration
Recommended starting dose:
In patients currently not treated with metformin, initiate Lijenta-MX treatment with 5 mg Linagliptin/1000 mg Metformin Hydrochloride extended-release once daily with a meal.In patients already treated with Metformin, start Lijenta-MX with 5 mg of Linagliptin total daily dose and a similar total daily dose of Metformin once daily with a meal.In patients already treated with Linagliptin and Metformin or Lijenta-M, switch to Lijenta-MX containing 5 mg of Linagliptin total daily dose and a similar total daily dose of Metformin once daily with a meal.
Lijenta-MX 5 mg Linagliptin/1000 mg Metformin Hydrochloride extended-release tablet should be taken as a single tablet once daily. Patients using 2.5 mg Linagliptin/1000 mg Metformin extended release tablets should take two tablets together once daily.
Contraindication
Precaution
Side Effects
Drug Interaction
Overdose
Linagliptin
During controlled clinical trials in healthy subjects, with single doses of up to 600 mg of linagliptin (equivalent to 120 times the recommended daily dose), there were no dose-related clinical adverse drug reactions.
Metformin
Overdose of metformin has occurred in case of ingestion of amounts greater than 50 grams. Hypoglycemia was reported in approximately 10% of cases, but no causal association with metformin has been established. Lactic acidosis has been reported in approximately 32% of metformin overdose cases.