- Stock: In Stock
- Brand: Acme Laboratories Limited
- Product ID: Ebastine
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Rhitin 10 mg Tablet
Description
Rhitin (Ebastine) is a second generation, non-sedating, longacting histamine antagonist with selective H1 receptor antagonist activity. After repeated administration, inhibition of peripheral receptors remains at a constant level. Ebastine is rapidly absorbed and undergoes extensive first pass metabolism following oral administration. Ebastine is almost totally converted to the pharmacologically active acid metabolite, carebastine.
Composition
Each film-coated tablet contains Ebastine BP 10 mg.
Indications
Seasonal and perennial allergic rhinitis such as sneezing, runny nose, itching in the eyes and nose.
Chronic idiopathic urticaria (an allergic skin rash) such as itching, hives (localized skin redness and swelling).
Dosage and Administration
Allergic Rhinitis: 10 mg (1 tablet) once daily.
Chronic idiopathic urticaria: 10 mg (1 tablet) once daily.
Rhitin may be taken with or without food.
OR AS DIRECTED BY THE PHYSICIAN.
Side Effects
The most common side-effects are headache, dry mouth and drowsiness. Other less commonly reported side effects include pharyngitis, abdominal pain, dyspepsia, asthenia, epistaxis, rhinitis, sinusitis, nausea and insomnia.
Contraindications
The use of ebastine is contraindicated in patients who have shown hypersensitivity to it.
Precautions
It is advisable to exercise caution when using ebastine in patients known to have the following conditions: long QT syndrome, hypokalaemia, treatment with any medicine known to produce an increase in QT interval or inhibit
CYPA4 enzyme systems such as azole antifungals and macrolide antibiotics.
Use in Pregnancy and Lactation
The safety of ebastine during pregnancy and lactation has not been established. So it should be avoided during pregnancy and lactation.
Drug Interactions
The interaction of ebastine in combination with either ketoconazole or erythromycin has been evaluated. A significant pharmacokinetic and pharmacodynamic interaction has been observed with these combination; Ebastine does not interact with the kinetics of theophylline, warfarin, cimetidine, diazepam or alcohol. When ebastine is administered with food, there is a 1.5 to 2.0 fold increase in the plasma levels and the AUC of the main active acid metabolite of ebastine. This increase does not alter the
Tmax. The administration of ebastine with food does not cause a modification in its clinical effect
Supply
Each box contains 3x10 tablets in blister strips.