Duocard 10 mg Tablet

Duocard 10 mg Tablet

Description

DUOCARD (Cilnidipine) is a dihydropyridine (DHP) type of calcium channel antagonist which inhibits sympathetic Ntype calcium channels in addition to vascular L-type calcium channels. The L-type calcium channel blockade by cilnidipine affects predominantly vascular smooth muscle, thereby producing vasodilation of peripheral resistance vessels and coronary arteries. The blockade of N-type Ca2+ channels affects predominantly peripheral nerve endings of sympathetic neurons, thereby dilating blood vessels by lowering plasma catecholamine levels. Thus

Simultaneous blockade of the L type and N type calcium channels results in [Type a quote from the document or the summary of an interesting point. You can position the text box anywhere in the document. Use the Drawing Tools tab to change the formatting of the pull quote text box.] significant reduction of the blood pressure without causing reflex tachycardia. Moreover the inhibition of N-type Ca2+ channels may provide a new strategy for the treatment of cardiovascular diseases with sympathetic over activity.

Composition

DUOCARD 5: Each film-coated tablet contains Cilnidipine INN 5 mg.

DUOCARD 10: Each film-coated tablet contains Cilnidipine INN 10 mg.

Indication

For the management of Hypertension.

Dosage and Administration

The recommended adult oral dosage of DUOCARD is 5-10 mg once daily. The dosage can be increased up to 20 mg, if needed or as directed by the Physician

Contraindications

Cilnidipine is contraindicated in cardiogenic shock, recent MI or acute unstable angina, severe aortic stenosis. Precautions Hypotension, poor cardiac reserve, heart failure. Sudden withdrawal may exacerbate angina. Discontinue in patients who experience ischemic pain following administration.

Use in Pregnancy & Lactation

In Pregnancy: No specific information about USFDA pregnancy category. Caution should be exercised during Cilnidipine use in pregnancy. In Lactation: Nursing mothers should consult a physician before taking Cilnidipine.

Adverse Reactions

Dizziness, flushing, headache, hypotension, peripheral edema, tachycardia, palpitations, GI disturbances, increased micturition frequency, lethargy, eye pain, depression, ischemic chest pain, cerebral or myocardial ischemia, transient blindness, rashes, fever, abnormal liver function, gingival hyperplasia, myalgia, tremor and impotence.

Drug Interactions

Other antihypertensives, aldesleukin, antipsychotics that cause hypotension, may modify insulin and glucose responses, quinidine; carbamazepine, phenytoin, rifampicin, cimetidine, erythromycin.

Supply

DUOCARD 5: Each box contains 2X10, 3X10 and 5 X 10 tablets in ALU-PVC blister.

DUOCARD 10: Each box contains 2X10, 3X10 and 5 X 10 tablets in ALU-PVC blister